Regional brain atrophy and functional disconnection in Broca's area in individuals at ultra-high risk for psychosis and schizophrenia.
Regional brain atrophy and functional disconnection in Broca's area in individuals at ultra-high risk for psychosis and schizophrenia.
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DOI：
10.1371/journal.pone.0051975
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Kwon JS
中科院分区：
文献类型：
--
作者：
Jung WH;Jang JH;Shin NY;Kim SN;Choi CH;An SK;Kwon JS
据报道，精神分裂症患者的认知能力异常，如语言流畅性和与认知相关的大脑区域，特别是布罗卡区。此外，以前的研究表明，布罗卡区的结构和功能异常与精神分裂症患者的临床症状和认知缺陷有关，这表明该区域的缺陷可能反映了精神分裂症的核心病理。因此，了解静息状态下该区域的结构体积和功能连通性如何随病程变化是很重要的。我们使用磁共振成像(MRI)测量了16名精神分裂症患者、16名超高危患者(UHR)和23名健康对照的Broca区的结构体积。我们还评估了语言流畅性，并使用静息状态功能磁共振分析了不同组之间功能连接模式的差异。UHR组的Broca区结构体积显著缩小，Broca区与额叶外侧和内侧皮质之间的功能连接性显著降低，认知能力下降。患者的功能连接性改变与其阳性症状相关。我们的结果表明，Broca区存在功能中断，即使在静息状态下，精神分裂症患者以及UHR中的这种疾病患者也是如此。这些改变可能导致他们的临床症状，这表明这是参与精神分裂症病理生理学的关键区域之一。
Abnormalities in cognitive abilities such as verbal fluency and in cognitive-related brain regions, particularly Broca’s area, have been reported in patients with schizophrenia. Additionally, previous studies have demonstrated that structural and functional abnormalities in Broca’s area were associated with clinical symptoms and cognitive deficits in patients with schizophrenia, suggesting that deficits in this area may reflect the core pathology of schizophrenia. Thus, it is important to understand how the structural volume and functional connectivity in this area changes at rest according to the course of the illness. We used magnetic resonance imaging (MRI) to measure the structural volume of Broca’s area as a region of interest in 16 schizophrenia, 16 ultra-high risk (UHR), and 23 healthy matched controls. We also assessed verbal fluency and analyzed differences across groups in the functional connectivity patterns using resting-state functional MRI. The UHR group showed significantly reduced structural volume in Broca’s area and significantly reduced functional connectivity between Broca’s area and the lateral and medial frontal cortex as well as decreased cognitive performance. Altered functional connectivity in patients was correlated with their positive symptoms. Our results suggest the existence of functional disconnections in Broca’s area, even during resting-states, among those with schizophrenia as well as those at UHR for this disorder. These alterations may contribute to their clinical symptoms, suggesting that this is one of the key regions involved in the pathophysiology of schizophrenia.
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