Effect of elevated basal insulin on cancer incidence and mortality in cancer incident patients: the Israel GOH 29-year follow-up study.
Effect of elevated basal insulin on cancer incidence and mortality in cancer incident patients: the Israel GOH 29-year follow-up study.
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DOI：
10.2337/dc11-1513
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发表时间：
2012-07
期刊：
影响因子：
16.2
通讯作者：
Chetrit A
中科院分区：
文献类型：
--
作者：
Dankner R;Shanik MH;Keinan-Boker L;Cohen C;Chetrit A
糖尿病与多种癌症有关。最近的证据表明，一些治疗糖尿病的方法会增加患癌症的风险。对于糖尿病前期内源性胰岛素与癌症风险之间的关系，我们所知甚少。我们根据基础胰岛素调查了29年来的累积癌症发病率和癌症发病率密度，研究对象为1695名非糖尿病男性和女性，来自4个种族，基线年龄为51.8±8.0岁。在基线后至少2年发生癌症的317名受试者（18.7%）的总死亡率被评估。在Cox比例风险模型中，经年龄、性别和种族调整后，最高胰岛素四分位数与其他三个四分位数的癌症发病率的全部位风险比为1.09 （95% CI 0.85-1.40）。BMI、吸烟和空腹血糖在该模型中无统计学意义。基础胰岛素水平与特定部位的癌症（乳腺癌、前列腺癌、结肠癌/直肠癌或膀胱癌）没有显著相关性。与低四分位数相比，在调整年龄、性别和种族后，高四分位数的空腹胰岛素使癌症患者总死亡率增加37% （95% CI 0.94-2.00, P = 0.097）。在随访期间，男性、年龄较大和北非血统与较高的死亡风险相关。这项长期队列研究可能提示基础胰岛素水平升高的作用，主要是作为癌症预后的负面预测因子。
Diabetes is associated with many forms of cancer. Recent evidence has suggested that some treatments for diabetes are associated with an increased cancer risk. Less is known about the association between endogenous insulin in the prediabetes state and cancer risk. We investigated cumulative cancer incidence and cancer incidence density over 29 years, according to basal insulin, in a cohort of 1,695 nondiabetic men and women of four ethnic origins, aged 51.8 ± 8.0 years at baseline. Total mortality among the 317 subjects (18.7%) who developed cancer at least 2 years after baseline was assessed. In a Cox proportional hazards model, the all-site hazard ratio of cancer incidence comparing the highest insulin quartile with the other three quartiles was 1.09 (95% CI 0.85–1.40), adjusted for age, sex, and ethnicity. BMI, smoking, and fasting blood glucose were not statistically significant in this model. Basal insulin level was not significantly associated with cancer of specific sites (breast, prostate, colon/rectum, or bladder). Fasting insulin in the upper quartile conferred a 37% increased risk for total mortality among cancer patients, adjusting for age, sex, and ethnic origin (95% CI 0.94–2.00, P = 0.097) compared with that of the lower quartiles. Male sex, older age, and North African origins were associated with a greater risk of mortality during follow-up time. This long-term cohort study may suggest a role for basal elevated insulin levels, mainly as a negative predictor in cancer prognosis.
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影响因子：
--
作者：
Cannata, Dara;Fierz, Yvonne;LeRoith, Derek
通讯作者：
LeRoith, Derek
影响因子：
15.9
作者：
MODAN, M;HALKIN, H;FUCHS, Z
通讯作者：
FUCHS, Z
影响因子：
7.7
作者：
Fierz Y;Novosyadlyy R;Vijayakumar A;Yakar S;LeRoith D
通讯作者：
LeRoith D
DOI：
10.1161/01.atv.12.12.1387
发表时间：
1992-12-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
CASASSUS, P;FONTBONNE, A;ESCHWEGE, E
通讯作者：
ESCHWEGE, E
影响因子：
15.9
作者：
PAPA, V;PEZZINO, V;VIGNERI, R
通讯作者：
VIGNERI, R