Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation.
Hemodynamic analysis for stenosis microfluidic model of thrombosis with refined computational fluid dynamics simulation.
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DOI：
10.1038/s41598-021-86310-2
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发表时间：
2021-03-25
影响因子：
4.6
通讯作者：
Ju LA
中科院分区：
文献类型：
--
作者：
Zhao YC;Vatankhah P;Goh T;Michelis R;Kyanian K;Zhang Y;Li Z;Ju LA
血流紊乱因其在血小板聚集和血栓形成中的关键作用而日益被认识到。已经开发了具有驼峰形收缩的微流体来模拟微血管狭窄并重现流动扰动的促血栓形成作用。然而，微流体血液动力学的物理决定因素并没有完全定义。在这里，我们报告了一种改进的计算流体动力学（CFD）模拟方法，以高精度绘制狭窄区域的剪切速率（γ）和壁面剪切应力（τ）分布。使用带有灵敏度验证的超细网格，我们的CFD结果表明，在确定狭窄处的γ和τ分布时，狭窄水平（S）比体剪切速率（γ0）和收缩角（α）更占主导地位。相反，α在控制剪切速率梯度（γ′）分布方面起重要作用，而它对峰值γ表现出微妙的影响。为了研究粘度效应，我们采用广义幂律模型来模拟血液流动作为非牛顿流体，与水介质的牛顿模拟相比，γ分布的差异可以忽略不计。总之，我们改进的CFD方法代表了一种全面的方法来检查三维微流体血液动力学并指导微制造设计。将其与血液学实验相结合，有望促进对血栓形成和血小板机械生物学中流变学效应的理解。
Disturbed blood flow has been increasingly recognized for its critical role in platelet aggregation and thrombosis. Microfluidics with hump shaped contractions have been developed to mimic microvascular stenosis and recapitulate the prothrombotic effect of flow disturbance. However the physical determinants of microfluidic hemodynamics are not completely defined. Here, we report a refined computational fluid dynamics (CFD) simulation approach to map the shear rate (γ) and wall shear stress (τ) distribution in the stenotic region at high accuracy. Using ultra-fine meshing with sensitivity verification, our CFD results show that the stenosis level (S) is dominant over the bulk shear rate (γ0) and contraction angle (α) in determining γ and τ distribution at stenosis. In contrast, α plays a significant role in governing the shear rate gradient (γ′) distribution while it exhibits subtle effects on the peak γ. To investigate the viscosity effect, we employ a Generalized Power-Law model to simulate blood flow as a non-Newtonian fluid, showing negligible difference in the γ distribution when compared with Newtonian simulation with water medium. Together, our refined CFD method represents a comprehensive approach to examine microfluidic hemodynamics in three dimensions and guide microfabrication designs. Combining this with hematological experiments promises to advance understandings of the rheological effect in thrombosis and platelet mechanobiology.
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DOI：
10.1111/j.1549-8719.2010.00056.x
发表时间：
2010-11
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Fedosov DA;Caswell B;Popel AS;Karniadakis GE
通讯作者：
Karniadakis GE
影响因子：
10.4
作者：
Jackson, S. P.;Nesbitt, W. S.;Westein, E.
通讯作者：
Westein, E.
影响因子：
19.6
作者：
Ballermann, BJ;Dardik, A;Liu, AL
通讯作者：
Liu, AL
影响因子：
7.4
作者：
Hansen, Caroline E.;Lam, Wilbur A.
通讯作者：
Lam, Wilbur A.
影响因子：
2.4
作者：
Lee, Seung E.;Lee, Sang-Wook;Fischer, Paul F.;Bassiouny, Hisham S.;Loth, Francis
通讯作者：
Loth, Francis