Speech‐in‐noise understanding in older age: The role of inhibitory cortical responses
Speech‐in‐noise understanding in older age: The role of inhibitory cortical responses
复制标题
老年人的语音理解：抑制性皮质反应的作用
DOI：
10.1111/ejn.14573
复制
发表时间：
2020
影响因子：
3.4
通讯作者：
Schumann
中科院分区：
文献类型：
--
作者：
Schumann
衰老过程中语音噪声（SIN）识别背后的中枢听觉加工研究主要涉及听觉脑干和皮层中语音神经表征的退化。对抑制功能的衰老相关下降的关注较少，抑制功能降低了抑制无关感觉输入分心的能力。在反应抑制范式中，年轻人和老年人在脑磁图记录期间听三种短声音的序列。将皮层P30反应和40 Hz瞬态γ反应的振幅与年龄、听力损失和SIN表现进行比较。最后一次和第一次反应之间的P30振幅比表明，与年轻听众相比，老年人的感觉门控减少了。感觉门控在老年人中与年龄相关，但与听力损失和SIN理解无关。瞬态伽马响应表现出较少的响应抑制。然而，γ振幅随年龄和SIN损失而增加。线性多变量模型的比较表明，伽马振幅与SIN表现之间的脑行为关系比伽马与年龄或听力损失之间的关系更强。这些发现支持了一种假设，即与衰老相关的抑制和兴奋神经机制之间的平衡改变改变了伽马振荡的产生，从而影响了感知结合，从而影响了SIN的理解能力。综上所述，老年人的SIN识别受感觉水平的中央听觉加工的影响较小，这表明了感觉门控，但在知觉组织水平上受到强烈的影响，这表明了与伽马反应的相关性。
Studies of central auditory processing underlying speech‐in‐noise (SIN) recognition in aging have mainly concerned the degrading neural representation of speech sound in the auditory brainstem and cortex. Less attention has been paid to the aging‐related decline of inhibitory function, which reduces the ability to suppress distraction from irrelevant sensory input. In a response suppression paradigm, young and older adults listened to sequences of three short sounds during MEG recording. The amplitudes of the cortical P30 response and the 40‐Hz transient gamma response were compared with age, hearing loss and SIN performance. Sensory gating, indicated by the P30 amplitude ratio between the last and the first responses, was reduced in older compared to young listeners. Sensory gating was correlated with age in the older adults but not with hearing loss nor with SIN understanding. The transient gamma response expressed less response suppression. However, the gamma amplitude increased with age and SIN loss. Comparisons of linear multi‐variable modeling showed a stronger brain–behavior relationship between the gamma amplitude and SIN performance than between gamma and age or hearing loss. The findings support the hypothesis that aging‐related changes in the balance between inhibitory and excitatory neural mechanisms modify the generation of gamma oscillations, which impacts on perceptual binding and consequently on SIN understanding abilities. In conclusion, SIN recognition in older age is less affected by central auditory processing at the level of sensation, indicated by sensory gating, but is strongly affected at the level of perceptual organization, indicated by the correlation with the gamma responses.
登录
查看更多内容
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
影响因子：
5.3
作者：
Alain, Claude;McDonald, Kelly L.
通讯作者：
McDonald, Kelly L.
40 Hz-EEG 与听觉诱发电位的中潜伏期反应之间的关联。
影响因子：
2.2
作者：
E.rol Başar;Bruce R. Rosen;C. Başar;F. Greitschus
通讯作者：
F. Greitschus
DOI：
10.1523/jneurosci.16-08-02788.1996
发表时间：
1996-04
期刊：
--
影响因子：
--
作者：
M. Steriade;D. Contreras;F. Amzica;lgor Timofeev
通讯作者：
M. Steriade;D. Contreras;F. Amzica;lgor Timofeev
影响因子：
--
作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman
通讯作者：
C. Siegel;M. Waldo;G. Mizner;L. Adler;R. Freedman