Expression of insulin pathway genes during the period of caste determination in the honey bee, Apis mellifera.
Expression of insulin pathway genes during the period of caste determination in the honey bee, Apis mellifera.
复制标题
蜂蜜蜜蜂Apis Mellifera中种姓测定期间胰岛素途径基因的表达。
DOI：
10.1111/j.1365-2583.2006.00681.x
复制
发表时间：
2006-10
影响因子：
2.6
通讯作者：
Evans, J. D.
中科院分区：
文献类型：
--
作者：
Wheeler, D. E.;Buck, N.;Evans, J. D.
雌性蜜蜂有两个种姓：蜂王和工蜂。发育命运由幼虫的饮食决定。通过蜜蜂基因组测序联盟提供的编码序列允许采用基于途径的方法来理解种姓决定。我们检查了胰岛素信号通路的几个基因的表达，该通路对于基于营养的生长调节至关重要。我们发现一种胰岛素样肽在蜂王而非工蜂幼虫中表达水平非常高。此外，在第二幼虫龄期间，胰岛素受体基因在蜂王幼虫中表达水平较高。这些结果表明，胰岛素途径是研究饮食与种姓决定和分化涉及的下游信号之间关系的一个令人信服的候选途径。
Female honeybees have two castes, queens and workers. Developmental fate is determined by larval diet. Coding sequences made available through the Honey Bee Genome Sequencing Consortium allow for a pathway-based approach to understanding caste determination. We examined the expression of several genes of the insulin signalling pathway, which is central to regulation of growth based on nutrition. We found one insulin-like peptide expressed at very high levels in queen but not worker larvae. Also, the gene for an insulin receptor was expressed at higher levels in queen larvae during the 2nd larval instar. These results demonstrate that the insulin pathway is a compelling candidate for pursing the relationship between diet and downstream signals involved in caste determination and differentiation.
登录
查看更多内容
影响因子：
2.2
作者：
Glasscock, JM;Mizoguchi, A;Rachinsky, A
通讯作者：
Rachinsky, A
影响因子：
2.7
作者：
RACHINSKY, A;STRAMBI, C;HARTFELDER, K
通讯作者：
HARTFELDER, K
影响因子：
2.2
作者：
Stabe, HA
通讯作者：
Stabe, HA
DOI：
10.1016/0305-0491(85)90400-6
发表时间：
1985-01-01
影响因子：
2.2
作者：
OCONNOR, KJ;BAXTER, D
通讯作者：
BAXTER, D
影响因子：
11.8
作者：
Britton, JS;Lockwood, WK;Edgar, BA
通讯作者：
Edgar, BA