Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.
Possible pro-carcinogenic association of endotoxin on lung cancer among Shanghai women textile workers.
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DOI：
10.1038/bjc.2014.308
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发表时间：
2014-07-29
影响因子：
8.8
通讯作者：
Thomas, D. B.
中科院分区：
文献类型：
--
作者：
Checkoway, H.;Lundin, J. I.;Costello, S.;Ray, R.;Li, W.;Eisen, E. A.;Astrakianakis, G.;Seixas, N.;Applebaum, K.;Gao, D. L.;Thomas, D. B.
内毒素（脂多糖）是许多环境中广泛存在的污染物。自20世纪70年代以来，有普遍一致的证据表明与职业性内毒素暴露相关的肺癌风险降低。我们更新了一项嵌套在中国上海267400名纺织女工队列中的病例队列研究。我们比较了1456例在1989-2006年诊断出的肺癌病例的暴露史与3022名在随访结束时没有肺癌的工人的参考子队列。我们应用考克斯比例风险模型来估计年龄和吸烟、滞后0年、10年和20年的累积暴露以及首次暴露后15年和>15年的时间窗的风险-反应趋势。我们没有观察到累积暴露与肺癌之间的关联，无论滞后时间。相比之下，按接触时间窗进行的分析显示，对于首次接触后15年以上发生的接触，在最高的三个接触五分位数处的相对风险略有升高，但在统计学上不显著（1.27）。这些发现并不支持内毒素的保护作用，但提示随着首次暴露时间的增加，可能会促进肺癌的发生。
Endotoxin (lipopolysaccharide) is a widespread contaminant in many environmental settings. Since the 1970s, there has been generally consistent evidence indicating reduced risks for lung cancer associated with occupational endotoxin exposure. We updated a case–cohort study nested within a cohort of 267 400 female textile workers in Shanghai, China. We compared exposure histories of 1456 incident lung cancers cases diagnosed during 1989–2006 with those of a reference subcohort of 3022 workers who were free of lung cancer at the end of follow-up. We applied Cox proportional hazards modelling to estimate exposure–response trends, adjusted for age and smoking, for cumulative exposures lagged by 0, 10, and 20 years, and separately for time windows of ⩽15 and >15 years since first exposure. We observed no associations between cumulative exposure and lung cancer, irrespective of lag interval. In contrast, analyses by exposure time windows revealed modestly elevated, but not statistically significant relative risks (∼1.27) at the highest three exposure quintiles for exposures that occurred >15 years since first exposure. The findings do not support a protective effect of endotoxin, but are suggestive of possible lung cancer promotion with increasing time since first exposure.
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影响因子：
3.5
作者：
CHRISTIANI, DC;WEGMAN, DH;OLENCHOCK, SA
通讯作者：
OLENCHOCK, SA
影响因子：
10
作者：
Peters S;Kromhout H;Olsson AC;Wichmann HE;Brüske I;Consonni D;Landi MT;Caporaso N;Siemiatycki J;Richiardi L;Mirabelli D;Simonato L;Gustavsson P;Plato N;Jöckel KH;Ahrens W;Pohlabeln H;Boffetta P;Brennan P;Zaridze D;Cassidy A;Lissowska J;Szeszenia-Dabrowska N;Rudnai P;Fabianova E;Forastiere F;Bencko V;Foretova L;Janout V;Stücker I;Dumitru RS;Benhamou S;Bueno-de-Mesquita B;Kendzia B;Pesch B;Straif K;Brüning T;Vermeulen R
通讯作者：
Vermeulen R
影响因子：
2.3
作者：
Agalliu, Ilir;Costello, Sadie;Eisen, Ellen A.
通讯作者：
Eisen, Ellen A.
DOI：
10.1080/15459620600793672
发表时间：
2006-08-01
影响因子：
2
作者：
Astrakianakis, George;Seixas, Noah;Checkoway, Harvey
通讯作者：
Checkoway, Harvey
影响因子：
10.3
作者：
Astrakianakis, George;Seixas, Noah S.;Checkoway, Harvey
通讯作者：
Checkoway, Harvey