Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.
Effects of age on the hippocampus and verbal memory in adults with autism spectrum disorder: Longitudinal versus cross-sectional findings.
复制标题
DOI：
10.1002/aur.2797
复制
发表时间：
2022-10
期刊：
影响因子：
4.7
通讯作者：
Braden, B. Blair
中科院分区：
文献类型：
--
作者：
Pagni, Broc A.;Walsh, Melissa J. M.;Ofori, Edward;Chen, Kewei;Sullivan, Georgia;Alvar, Jocelyn;Monahan, Leanna;Guerithault, Nicolas;Delaney, Shanna;Braden, B. Blair
关键词：
研究患有自闭症谱系障碍 (ASD) 的成年人的衰老研究正在不断增多，但仍需要进行纵向研究。与神经正常（NT）成年人相比，自闭症成年人患痴呆症、海马体积和穹窿完整性改变以及言语记忆困难的风险增加。这项研究考察了患有 ASD 的中年成人与匹配的 NT 组的纵向衰老情况，并将研究结果与广泛成人年龄范围内的横截面年龄效应进行了比较。参与者为 194 名患有自闭症谱系障碍 (n=106；74 名男性) 和不患有自闭症谱系障碍 (n=88；52 名男性) 的成年人，年龄 18-71 岁。两次就诊（相隔 2-3 岁）的参与者（n=45；40-70 年龄范围）被纳入纵向分析。分别通过 T1 加权 MRI、弥散张量成像和 Rey 听觉言语学习测试测量海马体积、穹窿分数各向异性 (FA) 和言语记忆。纵向混合模型用于海马系统变量，可靠的变化指数类别用于 AVLT 分析。多变量回归用于横断面分析。与 NT 相比，患有 ASD 的中年成年人的纵向海马体积损失更大，并且更有可能表现出有临床意义的短期记忆下降。相比之下，年龄增长与短期记忆恶化之间的横断面关联在 NT 患者中被发现，但在自闭症成人中却没有。在广泛的横截面年龄范围内，发现 ASD 患者穹窿 FA 和长期记忆减少。这些初步的纵向研究结果表明，自闭症谱系障碍患者海马体积损失加速，言语短期记忆的临床意义下降率略高。相互矛盾的横截面和纵向结果强调了自闭症成人纵向衰老研究的重要性。与神经正常（NT）成年人相比，自闭症成年人患痴呆症的风险增加，大脑记忆结构存在差异，并且记忆困难。然而，目前还没有任何出版物能够跟踪同一名中年自闭症成年人随着时间的推移，观察他们的大脑和记忆如何变化。我们在一个小型中年自闭症样本中的初步发现表明，与 NT 相比，关键的记忆大脑结构海马体可能会在 2-3 年内萎缩得更快，并且短期记忆对某些人来说可能变得更具挑战性。在广泛的成年人范围内，自闭症成年人与海马体连接的完整性也降低，长期记忆面临更大的挑战。在我们广泛年龄范围的较大样本中，结果并未暗示上述加速衰老的模式。这强调了更多关于自闭症的衰老研究的重要性，尤其是对人们进行长期跟踪研究的重要性。
Research studying aging in adults with autism spectrum disorder (ASD) is growing, but longitudinal work is needed. Autistic adults have increased risk of dementia, altered hippocampal volumes and fornix integrity, and verbal memory difficulties compared to neurotypical (NT) adults. This study examined longitudinal aging in middle-age adults with ASD versus a matched NT group, and compared findings to cross-sectional age effects across a broad adult age range. Participants were 194 adults with (n=106; 74 male) and without (n=88; 52 male) ASD, ages 18–71. Participants (n=45; 40–70 age range) with two visits (2–3 years apart) were included in a longitudinal analysis. Hippocampal volume, fornix fractional anisotropy (FA), and verbal memory were measured via T1-weighted MRI, diffusion tensor imaging, and the Rey Auditory Verbal Learning Test, respectively. Longitudinal mixed models were used for hippocampal system variables and reliable change index categories were used for AVLT analyses. Multi-variate regression was used for cross-sectional analyses. Middle-age adults with ASD had greater longitudinal hippocampal volume loss and were more likely to show clinically meaningful decline in short-term memory, compared to NT. In contrast, cross-sectional associations between increasing age and worsening short-term memory were identified in NT, but not autistic adults. Reduced fornix FA and long-term memory in ASD were found across the broad cross-sectional age range. These preliminary longitudinal findings suggest accelerated hippocampal volume loss in ASD and slightly higher rates of clinically-meaningful decline in verbal short-term memory. Contradictory cross-sectional and longitudinal results underscore the importance of longitudinal aging research in autistic adults. Autistic adults have increased risk of dementia, differences in brain memory structures, and difficulty with memory compared to neurotypical (NT) adults. However, there are no publications that follow the same middle-age autistic adults over time to see how their brain and memory change. Our preliminary findings in a small middle-age autism sample suggest a key memory brain structure, the hippocampus, may shrink faster over 2–3 years compared to NT, and short-term memory may become more challenging for some. Across a broad adult range, autistic adults also had reduced integrity of connections to the hippocampus and greater challenges with long-term memory. In our larger sample across a broad age range, the results did not hint at this aforementioned pattern of accelerated aging. This underscores the importance of more aging research in autism, and especially research where people are followed over time.
登录
查看更多内容
影响因子：
2.5
作者：
Braden, B. Blair;Riecken, Cory
通讯作者：
Riecken, Cory
影响因子：
4.8
作者：
Williams CM;Peyre H;Toro R;Beggiato A;Ramus F
通讯作者：
Ramus F
影响因子：
5.7
作者：
Kodiweera C;Alexander AL;Harezlak J;McAllister TW;Wu YC
通讯作者：
Wu YC
影响因子：
2.5
作者：
Lee, Jee Eun;Bigler, Erin D.;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
10.6
作者：
Bastiaansen, Jojanneke A.;Thioux, Marc;Keysers, Christian
通讯作者：
Keysers, Christian