Cross-Talk Between Ionic and Nanoribbon Current Signals in Graphene Nanoribbon-Nanopore Sensors for Single-Molecule Detection.
Cross-Talk Between Ionic and Nanoribbon Current Signals in Graphene Nanoribbon-Nanopore Sensors for Single-Molecule Detection.
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DOI：
10.1002/smll.201502134
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发表时间：
2015-12-16
期刊：
影响因子：
--
通讯作者：
Drndić M
中科院分区：
文献类型：
--
作者：
Puster M;Balan A;Rodríguez-Manzo JA;Danda G;Ahn JH;Parkin W;Drndić M
纳米孔现在不仅被用作离子电流传感器，而且还被用作一种方法来定位分子，使其具有更高的灵敏度和/或选择性。其中一个例子是嵌入石墨烯纳米带（GNR）晶体管中的固态纳米孔。这种装置具有更高带宽测量所需的高电导率，并且由于其单原子层厚度，可以提高测量的空间分辨率。在这里，我们展示了双链DNA （dsDNA）易位过程中通过纳米孔的离子电流的双通道测量，以及由于周围电位变化而引起的邻近GNR的同步响应。我们观察到由于两个测量通道之间的电容耦合而产生的串扰，在DNA易位期间导致GNR中的瞬态响应；然而，由于DNA易位过程中局部溶液电位的变化，我们没有观察到通过电场效应响应对器件电导率的调制。场效应响应将与GNR源漏电压（Vds）成比例，而电容耦合不与Vds成比例。为了充分利用这类传感器的高带宽潜力，必须提高其场效应响应。我们提出了势场计算，勾勒出在器件参数空间内检测的相位图，为此类器件的未来优化绘制了路线图。
Nanopores are now being used not only as an ionic current sensor but also as a means to localize molecules near alternative sensors with higher sensitivity and/or selectivity. One example is a solid-state nanopore embedded in a graphene nanoribbon (GNR) transistor. Such a device possesses the high conductivity needed for higher bandwidth measurements and, because of its single-atomic-layer thickness, could improve the spatial resolution of the measurement. Here we show two-channel measurements of ionic current through the nanopore during double-stranded DNA (dsDNA) translocation, along with the simultaneous response of the neighboring GNR due to changes in the surrounding electric potential. We observe cross-talk originating from capacitive coupling between the two measurement channels, resulting in a transient response in the GNR during DNA translocation; however, we do not observe a modulation in device conductivity via an electric field effect response, due to changes in local solution potential during DNA translocation. A field effect response would scale with GNR source-drain voltage (Vds), whereas the capacitive coupling does not scale with Vds. In order to take advantage of the high bandwidth potential of such sensors, the field effect response must be enhanced. We present potential field calculations to outline a phase diagram for detection within the device parameter space, charting a roadmap for future optimization of such devices.
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