An automatic approach for calibrating dielectric bone properties by combining finite-element and optimization software tools
An automatic approach for calibrating dielectric bone properties by combining finite-element and optimization software tools
复制标题
通过结合有限元和优化软件工具来自动校准介电骨特性的方法
DOI：
10.1080/10255842.2015.1131980
复制
发表时间：
2016
影响因子：
1.6
通讯作者：
Bader R
中科院分区：
文献类型：
--
作者：
Kluess D;Mittelmeier W;van Rienen U;Bader R
人骨的介电特性是电磁刺激改善骨再生所需的最基本输入之一。由于骨结构的复杂性，测量骨的电特性是一项困难的任务。因此，提出了一种自动校准骨电特性的方法。数值方法包括三个步骤：从实验数据生成输入，进行数值模拟，校准骨介电性能。作为一个例子，在20 Hz的兔股骨远端的介电性能进行了校准。校准过程被认为是一个优化过程，目的是找到最佳的电介质骨特性，匹配大多数的数值计算模拟和实验测量的数据集。优化软件工具iSIGHT结合有限元求解器COMSOL Multiphysics自动进行优化。结果表明，在20 Hz时，兔股骨远端皮质骨的最佳电导率和相对介电常数分别为0.09615 S/m和19522，松质骨的最佳电导率和相对介电常数分别为0.14913 S/m和1561507。所提出的方法是一个潜在的工具，用于识别整个骨体积的现实介电特性。所提出的将iSIGHT与COMSOL相结合的方法适用于设计植入式电刺激器械或优化电刺激参数以改善骨再生。
The dielectric properties of human bone are one of the most essential inputs required by electromagnetic stimulation for improved bone regeneration. Measuring the electric properties of bone is a difficult task because of the complexity of the bone structure. Therefore, an automatic approach is presented to calibrate the electric properties of bone. The numerical method consists of three steps: generating input from experimental data, performing the numerical simulation, and calibrating the bone dielectric properties. As an example, the dielectric properties at 20 Hz of a rabbit distal femur were calibrated. The calibration process was considered as an optimization process with the aim of finding the optimum dielectric bone properties that match most of the numerically calculated simulation and experimentally measured data sets. The optimization was carried out automatically by the optimization software tool iSIGHT in combination with the finite-element solver COMSOL Multiphysics. As a result, the optimum conductivity and relative permittivity of the rabbit distal femur at 20 Hz were found to be 0.09615 S/m and 19522 for cortical bone and 0.14913 S/m and 1561507 for cancellous bone, respectively. The proposed method is a potential tool for the identification of realistic dielectric properties of the entire bone volume. The presented approach combining iSIGHT with COMSOL is applicable to, amongst others, designing implantable electro-stimulative devices or the optimization of electrical stimulation parameters for improved bone regeneration.
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DOI：
10.1007/978-3-642-81193-7_2
发表时间：
1978
期刊：
The Journal of bone and joint surgery. American volume
影响因子：
--
作者：
W. Sansen;F. D. Dijcker;S. Stan;J. C. Mulier
通讯作者：
J. C. Mulier
电刺激过程中生物组织能量分布的数值模拟
影响因子：
--
作者：
Momcilo Prodanovic;Jovana Malešević;Marko Filipovic;T. Jevtic;G. Bijelic;N. Malešević
通讯作者：
N. Malešević
人体股骨头电磁刺激电场分布评价
影响因子：
1.9
作者：
Souffrant R;Kluess D;Ellenrieder M;Mittelmeier W;van Rienen U;Bader R
通讯作者：
Bader R
影响因子：
4.2
作者：
S. Singh;S. Saha
通讯作者：
S. Saha
DOI：
10.2106/00004623-198163040-00001
发表时间：
1981-01-01
影响因子：
5.3
作者：
BASSETT, CAL;MITCHELL, SN;GASTON, SR
通讯作者：
GASTON, SR