Versatile lifestyles of Edwardsiella: Free-living, pathogen, and core bacterium of the aquatic resistome.

Versatile lifestyles of Edwardsiella: Free-living, pathogen, and core bacterium of the aquatic resistome.
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DOI:
10.1080/21505594.2021.2006890
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发表时间:
2022-12
期刊:
影响因子:
5.2
通讯作者:
--
中科院分区:
生物学2区
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爱德华氏菌在水生环境中以个体浮游细胞或群落生物膜的形式存在。这些生物会遇到多种压力,包括盐度,pH值,温度和营养物质的变化。病原菌如E.杀鱼动物,可以在鱼的宿主中繁殖。此外,爱德华氏菌(E. tarda),可以在染色体和/或质粒上携带抗生素抗性基因(ARG),其可以通过水平基因转移传递到微生物组。E. tarda在水生抗性组中起核心作用。Edwardsiela使用分子开关(RpoS和EsrB)来控制基因表达,以在不同环境中生存。我们推测,自由生活的爱德华氏菌可以过渡到主机生活,反之亦然,使用类似的分子开关。了解这种转变可以帮助我们了解其他类似的水生细菌如何从自由生活转变为病原体。这些知识可用于设计减缓ARG传播的方法,并防止水产养殖和临床环境中的疾病爆发。
Edwardsiella species in aquatic environments exist either as individual planktonic cells or in communal biofilms. These organisms encounter multiple stresses, include changes in salinity, pH, temperature, and nutrients. Pathogenic species such as E. piscicida, can multiply within the fish hosts. Additionally, Edwardsiella species (E. tarda), can carry antibiotic resistance genes (ARGs) on chromosomes and/or plasmids, that can be transmitted to the microbiome via horizontal gene transfer. E. tarda serves as a core in the aquatic resistome. Edwardsiela uses molecular switches (RpoS and EsrB) to control gene expression for survival in different environments. We speculate that free-living Edwardsiella can transition to host-living and vice versa, using similar molecular switches. Understanding such transitions can help us understand how other similar aquatic bacteria switch from free-living to become pathogens. This knowledge can be used to devise ways to slow down the spread of ARGs and prevent disease outbreaks in aquaculture and clinical settings.
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