The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes.
The change and effect of endothelial progenitor cells in pig with multiple organ dysfunction syndromes.
复制标题
多器官功能障碍综合征猪内皮祖细胞的变化及影响.
DOI：
10.1186/cc7968
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
Fang GE
中科院分区：
文献类型：
--
作者：
Luo TH;Wang Y;Lu ZM;Zhou H;Xue XC;Bi JW;Ma LY;Fang GE
内皮祖细胞功能障碍和数量减少可能在创伤或严重脓毒症所致器官功能障碍的发生中起重要作用。本研究旨在通过检测严重脓毒症所致多器官功能障碍综合征(MODS)患者外周血中内皮祖细胞的数量和功能变化，探讨其在MODS发病机制中的作用。将40头猪随机分为失血性休克+复苏+内毒素血症组(实验组，n=20)和对照组(对照组，n=20)。分析两组不同时间内皮祖细胞的数量和功能，包括黏附能力、迁移能力和血管生成能力。实验组动物全部发生MODS(100%)，其中17只(85%)死于MODS，对照组动物MODS发生率及死亡率均为0%(P<；0.01)。实验组内皮祖细胞数量、迁移能力和黏附能力随MODS程度加重而急剧下降，但血管生成功能逐渐增强，直至死亡。内皮祖细胞功能的下降先于内皮祖细胞数量的减少。内皮祖细胞数量和功能的减少发生在MODS发生之前。首次观察到内皮祖细胞的数量和功能在MODS的进展过程中急剧下降，并先于MODS的发生。内皮祖细胞数量和功能的减少可能是MODS的主要发病因素之一。
The dysfunction and decrease of endothelial progenitor cells (EPCs) may play a very important role in the initiation of organ dysfunction caused by trauma or severe sepsis. We aim to measure the number and function of EPCs in the progression of multiple organ dysfunction syndromes (MODS) caused by severe sepsis, which may help to understand the pathogenesis of MODS by the changing of EPCs. A total of 40 pigs were randomly divided into two groups, which were subjected to hemorrhagic shock, resuscitation and endotoxemia (experimental group, n = 20) or acted as a control (control group, n = 20). The number and function of EPCs including adhesive, migratory and angiogenesis capacities were analyzed at different times in both groups. All the animals in the experimental group developed MODS (100%) and 17 of 20 animals (85%) died due to MODS; the incidence of MODS and death of the animals in the control group were 0% (P < 0.01). The number, migratory and adhesive capacities of EPCs decreased sharply in the animals of the experimental group corresponding to the increasing severities of MODS, but the angiogenesis function increased gradually until death. The decrease in function of EPCs preceded the decrease in number of EPCs. The decrease in number and function of EPCs occurred prior to the occurrence of MODS. For the first time, it was observed that the number and function of EPCs decreased sharply in the progression of MODS and that it was prior to the occurrence of MODS. The decrease in number and function of EPCs may be one of the main pathogenic factors of MODS.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
5.3
作者：
Mayr, F B;Spiel, A O;Jilma, B
通讯作者：
Jilma, B
影响因子：
2.3
作者：
Neumueller, Josef;Neumueller-Guber, Sylvia-Emanuela;Huber, Johannes
通讯作者：
Huber, Johannes
影响因子：
19.6
作者：
Bahlmann, FH;DeGroot, K;Fliser, D
通讯作者：
Fliser, D
DOI：
10.1177/039463200802100324
发表时间：
2008-07-01
影响因子：
3.5
作者：
Becchi, C.;Pillozzi, S.;Amedei, A.
通讯作者：
Amedei, A.