Fronto-striatal functional connectivity during response inhibition in alcohol dependence.
Fronto-striatal functional connectivity during response inhibition in alcohol dependence.
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DOI：
10.1111/adb.12013
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发表时间：
2013-05
影响因子：
3.4
通讯作者：
Ray LA
中科院分区：
文献类型：
--
作者：
Courtney KE;Ghahremani DG;Ray LA
不良的反应抑制与酒精依赖的发展有关，但人们对这种疾病中认知控制的神经通路如何受到影响知之甚少。此外，内源性阿片样物质水平可能影响抑制性控制途径的功能。本研究探讨了酒精依赖严重程度与反应抑制过程中额-纹状体网络功能连接之间的关系。本研究的第二个目的是测试μ-阿片受体（OPRM 1）基因的功能多态性（A118 G）的调节作用。20名酒精依赖者（6名女性，90%为白人，平均年龄29.4岁）在OPRM 1基因上进行前瞻性基因分型，在进行停止信号任务（SST）时进行血氧水平依赖（BOLD）功能性磁共振成像（fMRI）。使用心理生理相互作用（PPI）分析，酒精依赖的严重程度和功能连接内额-纹状体网络的反应抑制的重要性进行了评估。分析显示，更严重的酒精依赖与壳核和前额叶区域之间较弱的功能连接有关（例如，前额叶皮层、前扣带皮层和内侧前额叶皮层）。此外，OPRM 1基因型与差异反应抑制相关的功能连接相关。这项研究表明，更严重的酒精依赖的个人表现出较少的额叶连接与纹状体，认知控制网络的一个组成部分，反应抑制的重要。这些研究结果表明，额叶-纹状体通路的反应抑制被削弱，酒精中毒的进展。
Poor response inhibition has been implicated in the development of alcohol dependence, yet little is known about how neural pathways underlying cognitive control are affected in this disorder. Moreover, endogenous opioid levels may impact the functionality of inhibitory control pathways. This study investigated the relationship between alcohol dependence severity and functional connectivity of fronto-striatal networks during response inhibition in an alcohol dependent sample. A secondary aim of this study was to test the moderating effect of a functional polymorphism (A118G) of the µ-opioid receptor (OPRM1) gene. Twenty individuals with alcohol dependence (6 females; 90% Caucasian; mean age = 29.4) who were prospectively genotyped on the OPRM1 gene underwent blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) while performing a Stop Signal Task (SST). The relationship between alcohol dependence severity and functional connectivity within fronto-striatal networks important for response inhibition was assessed using psychophysiological interaction (PPI) analyses. Analyses revealed greater alcohol dependence severity associated with weaker functional connectivity between the putamen and prefrontal regions (e.g., the anterior insula, anterior cingulate, and medial prefrontal cortex) during response inhibition. Further, the OPRM1 genotype was associated with differential response inhibition-related functional connectivity. This study demonstrates that individuals with more severe alcohol dependence exhibit less frontal connectivity with the striatum, a component of cognitive control networks important for response inhibition. These findings suggest that the fronto-striatal pathway underlying response inhibition is weakened as alcoholism progresses.
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影响因子：
5.7
作者：
Congdon, Eliza;Mumford, Jeanette A.;Cohen, Jessica R.;Galvan, Adriana;Aron, Adam R.;Xue, Gui;Miller, Eric;Poldrack, Russell A.
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Poldrack, Russell A.
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影响因子：
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