Experimental validation of finite element predicted bone strain in the human metatarsal.
Experimental validation of finite element predicted bone strain in the human metatarsal.
复制标题
有限元预测人体跖骨骨应变的实验验证。
DOI：
10.1016/j.jbiomech.2017.06.010
复制
发表时间：
2017
影响因子：
2.4
通讯作者：
W. B. Edwards
中科院分区：
文献类型：
--
作者：
Anita Fung;L. L. Loundagin;W. B. Edwards
跖骨应力性骨折是运动员和军人常见的损伤。机械疲劳被认为在应力性骨折的病因中起重要作用，应力性骨折高度依赖于施加载荷产生的骨应变。本研究的目的是验证特定对象的有限元（FE）建模程序在人类跖骨骨应变预测。应变计测量了7个人体尸体脚的33个跖骨，这些跖骨受到悬臂弯曲的影响，并根据计算机断层扫描图像生成了受试者特定的有限元模型。有限元模型的材料属性使用已发布的密度-模量关系以及从优化技术中开发的密度-模量关系进行分配。通过跖骨的“训练集”（n = 17）建立了优化的关系，并通过“测试集”（n = 16）进行了交叉验证。已发表和优化的密度弹性方程提供的fe预测应变在训练集（r2≥0.95）和测试集（r2≥0.94）均与实验测量值高度相关；然而，优化方程相对于已发表的方程减少了10%至20%的最大误差，并导致实验测量和有限元预测之间的X = Y型关系。与跨越整个骨密度范围的单一方程相比，对小梁骨和皮质骨使用单独优化的密度-模量方程并不能改善应变预测。我们认为，具有优化材料属性分配的有限元模型具有必要的准确性，可以研究最小化跖骨应变的潜在干预措施，以防止应力性骨折的发生。
Metatarsal stress fracture is a common injury observed in athletes and military personnel. Mechanical fatigue is believed to play an important role in the etiology of stress fracture, which is highly dependent on the resulting bone strain from the applied load. The purpose of this study was to validate a subject-specific finite element (FE) modeling routine for bone strain prediction in the human metatarsal. Strain gauge measurements were performed on 33 metatarsals from seven human cadaveric feet subject to cantilever bending, and subject-specific FE models were generated from computed tomography images. Material properties for the FE models were assigned using a published density-modulus relationship as well as density-modulus relationships developed from optimization techniques. The optimized relationships were developed with a ‘training set’ of metatarsals (n = 17) and cross-validated with a ‘test set’ (n = 16). The published and optimized density elasticity equations provided FE-predicted strains that were highly correlated with experimental measurements for both the training (r2≥ 0.95) and test (r2≥ 0.94) sets; however, the optimized equations reduced the maximum error by 10% to 20% relative to the published equation, and resulted in an X = Y type of relationship between experimental measurements and FE predictions. Using a separate optimized density-modulus equation for trabecular and cortical bone did not improve strain predictions when compared to a single equation that spanned the entire bone density range. We believe that the FE models with optimized material property assignment have a level of accuracy necessary to investigate potential interventions to minimize metatarsal strain in an effort to prevent the occurrence of stress fracture.
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影响因子：
4.1
作者：
Wang, X;Shen, X;Agrawal, CM
通讯作者：
Agrawal, CM
影响因子：
4.1
作者：
SCHAFFLER, MB;RADIN, EL;BURR, DB
通讯作者：
BURR, DB
影响因子：
2.4
作者：
Zysset, PK;Guo, XE;Goldstein, SA
通讯作者：
Goldstein, SA
影响因子：
2.4
作者：
Morgan, EF;Bayraktar, HH;Keaveny, TM
通讯作者：
Keaveny, TM
影响因子：
2.2
作者：
RHO, JY;HOBATHO, MC;ASHMAN, RB
通讯作者：
ASHMAN, RB