Biomechanics and mechanobiology in functional tissue engineering.
Biomechanics and mechanobiology in functional tissue engineering.
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DOI：
10.1016/j.jbiomech.2014.04.019
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发表时间：
2014-06-27
影响因子：
2.4
通讯作者：
Baaijens, Frank P. T.
中科院分区：
文献类型：
--
作者：
Guilak, Farshid;Butler, David L.;Goldstein, Steven A.;Baaijens, Frank P. T.
组织工程领域不断扩大和成熟，一些产品现已进入临床使用，许多其他临床前和临床研究正在进行中。然而，在主要发挥生物力学功能的组织的修复或再生中仍然存在特定的挑战。此外，现在很清楚，细胞和支架之间的机械生物学相互作用可以严重影响细胞行为，即使在不起明显生物力学作用的组织和器官中。在过去的十年中，“功能性组织工程”领域已经发展成为组织工程的一个子领域，以解决组织工程中生物力学和机械生物学作用的挑战和问题。功能性组织工程最初是作为承重组织工程的一套原则和指导方针提出的，现已发展到包括几个相关领域，这些领域已被证明对组织修复和再生具有重要意义。这些主题包括在体内生物力学环境的测量和建模;天然组织，支架和修复组织的机械性能的定量分析;设计和评估工程组织的基本标准的发展;在体内和体外对天然和修复组织的生物力学因素的影响的调查;和组织生长和重塑的计算模型的开发和应用。在这里，我们进一步扩展了这一范式，并提供了过去十年在该领域取得的众多进展的例子。在设计过程中考虑这些原则将有望提高工程组织替代物的安全性、有效性和整体成功率。
The field of tissue engineering continues to expand and mature, and several products are now in clinical use, with numerous other preclinical and clinical studies underway. However, specific challenges still remain in the repair or regeneration of tissues that serve a predominantly biomechanical function. Furthermore, it is now clear that mechanobiological interactions between cells and scaffolds can critically influence cell behavior, even in tissues and organs that do not serve an overt biomechanical role. Over the past decade, the field of “functional tissue engineering” has grown as a subfield of tissue engineering to address the challenges and questions on the role of biomechanics and mechanobiology in tissue engineering. Originally posed as a set of principles and guidelines for engineering of load-bearing tissues, functional tissue engineering has grown to encompass several related areas that have proven to have important implications for tissue repair and regeneration. These topics include measurement and modeling of the in vivo biomechanical environment; quantitative analysis of the mechanical properties of native tissues, scaffolds, and repair tissues; development of rationale criteria for the design and assessment of engineered tissues; investigation of the effects biomechanical factors on native and repair tissues, in vivo and in vitro; and development and application of computational models of tissue growth and remodeling. Here we further expand this paradigm and provide examples of the numerous advances in the field over the past decade. Consideration of these principles in the design process will hopefully improve the safety, efficacy, and overall success of engineered tissue replacements.
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DOI：
10.1115/1.1318906
发表时间：
2000-12-01
影响因子：
1.7
作者：
Butler, DL;Goldstein, SA;Guilak, F
通讯作者：
Guilak, F
DOI：
10.1002/jbm.b.31686
发表时间：
2010-10
影响因子：
3.4
作者：
Chao, Pen-Hsiu Grace;Yodmuang, Supansa;Wang, Xiaoqin;Sun, Lin;Kaplan, David L.;Vunjak-Novakovic, Gordana
通讯作者：
Vunjak-Novakovic, Gordana
影响因子：
3.1
作者：
Boland, ED;Matthews, JA;Bowlin, GL
通讯作者：
Bowlin, GL
影响因子：
2.4
作者：
Buckley, Mark R.;Sarver, Joseph J.;Soslowsky, Louis J.
通讯作者：
Soslowsky, Louis J.
影响因子：
2.8
作者：
Boerckel, Joel D.;Kolambkar, Yash M.;Stevens, Hazel Y.;Lin, Angela S. P.;Dupont, Kenneth M.;Guldberg, Robert E.
通讯作者：
Guldberg, Robert E.