Biomimetic strategies for targeted nanoparticle delivery.
Biomimetic strategies for targeted nanoparticle delivery.
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DOI：
10.1002/btm2.10004
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发表时间：
2016-03
影响因子：
7.4
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Dehaini D;Fang RH;Zhang L
基于纳米颗粒的药物递送和成像平台在过去几十年中变得越来越受欢迎。在不同的设计参数，可以影响他们的性能，结合到纳米粒子表面的靶向功能已被广泛研究的主题。靶向制剂具有通过积极调节组织定位来改善功效和功能的能力。存在许多用于产生靶向纳米制剂的方法，包括使用定制的生物分子如抗体或适体。最近，大量的焦点已经放在利用直接在自然界中发现的靶向相互作用的仿生靶向策略上。这些策略是随着时间的推移通过进化过程精心选择的，以最大化功能，通常使科学家能够放弃与许多传统配体相关的专门发现过程，并有助于加速新型纳米颗粒制剂的开发。在这篇综述中，我们对这一不断发展的生物启发研究领域的最新工作进行了深入的分类和讨论。
Nanoparticle‐based drug delivery and imaging platforms have become increasingly popular over the past several decades. Among different design parameters that can affect their performance, the incorporation of targeting functionality onto nanoparticle surfaces has been a widely studied subject. Targeted formulations have the ability to improve efficacy and function by positively modulating tissue localization. Many methods exist for creating targeted nanoformulations, including the use of custom biomolecules such as antibodies or aptamers. More recently, a great amount of focus has been placed on biomimetic targeting strategies that leverage targeting interactions found directly in nature. Such strategies, which have been painstakingly selected over time by the process of evolution to maximize functionality, oftentimes enable scientists to forgo the specialized discovery processes associated with many traditional ligands and help to accelerate development of novel nanoparticle formulations. In this review, we categorize and discuss in‐depth recent works in this growing field of bioinspired research.
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影响因子：
3
作者：
Daniels, Tracy R.;Bernabeu, Ezequiel;Rodriguez, Jose A.;Patel, Shabnum;Kozman, Maggie;Chiappetta, Diego A.;Holler, Eggehard;Ljubimova, Julia Y.;Helguera, Gustavo;Penichet, Manuel L.
通讯作者：
Penichet, Manuel L.
影响因子：
2.9
作者：
DAVIE, EW;FUJIKAWA, K;KISIEL, W
通讯作者：
KISIEL, W
影响因子：
4.2
作者：
Dardevet L;Rani D;Aziz TA;Bazin I;Sabatier JM;Fadl M;Brambilla E;De Waard M
通讯作者：
De Waard M
影响因子：
3.6
作者：
CLARK, MA;JEPSON, MA;HIRST, BH
通讯作者：
HIRST, BH
影响因子：
12.4
作者：
Chen K;Chen X
通讯作者：
Chen X