Comparison of breast specific gamma imaging and molecular breast tomosynthesis in breast cancer detection: Evaluation in phantoms.
Comparison of breast specific gamma imaging and molecular breast tomosynthesis in breast cancer detection: Evaluation in phantoms.
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乳腺特异性伽马成像和分子乳腺断层合成在乳腺癌检测中的比较：体模评估。
DOI：
10.1118/1.4922398
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发表时间：
2015
期刊：
影响因子：
3.8
通讯作者：
Williams,MarkB
中科院分区：
文献类型：
--
作者：
Gong,Zongyi;Williams,MarkB
目的乳腺特异性伽马成像或分子乳腺成像（BSGI）获得乳腺内99mtc sestamibi分布的二维图像。分子乳腺断层合成（MBT）通过在有限的角度范围内获得多个投影来绘制3D示踪剂分布。在这里，作者比较了两种技术在空间分辨率、病变对比度和对比噪声比（CNR）方面的性能，在临床相关的sestamibi剂量和成像时间条件下进行幻像研究。方法测试的系统是由弗吉尼亚大学开发的Dilon 6800和MBT原型机。这两个系统包括一个像素化的碘化钠闪烁体，一个位置敏感光电倍增管阵列，和一个平行孔准直器。系统的有效面积和能量分辨率是相似的。系统灵敏度、空间分辨率、病变对比度和CNR分别使用培养皿、点源模体和乳房模体在两个深度测量模拟病变。获得单次BSGI投影。在±20°范围内获得5个MBT投影。对于这两种模式，总扫描计数密度与注射22 mCi (814 MBq) 99mtc - sestamibi后典型10分钟人体扫描中观察到的总扫描计数密度相当。为了评估减少示踪剂剂量的影响，投影图像的像素计数随后以2倍二项抽样，得到与注射活性约为11 mCi （407 MBq）相对应的图像。对Dilon 6800工作站默认显示的未处理（像素化）BSGI投影和插值（平滑）BSGI图像进行了分析。利用最大似然期望最大化算法从MBT投影中重建体积图像，并对提取的图像切片进行分析。结果在1.5 ~ 7.5 cm深度范围内，未处理投影图像的BSGI空间分辨率为5.6 ~ 11.5 mm，插值图像的BSGI空间分辨率为5.7 ~ 12.0 mm。在相同的范围内，片内MBT的空间分辨率为6.7-9.4 mm。在22 mCi或11 mCi剂量水平下成像的8个病变中，MBT相对于BSGI有5个病变对比度显着改善（p< 0.05）。在两种剂量水平下，MBT对8个病灶中的5个（水深为1.7 cm时的9.8、7.8、6.2 mm病灶和水深为4.5 cm时的9.8、7.8 mm病灶，p< 0.05）的CNR也有显著改善。6.2和4.9毫米病变位于水面以下4.5厘米处，在两种模式下，在两种活动水平下都不可见。结论在相同的剂量、成像时间和相似的检测器条件下，与BSGI相比，MBT具有更高的病灶对比度、更高的CNR和对深度依赖性较小的空间分辨率。
PurposeBreast specific gamma imaging or molecular breast imaging (BSGI) obtains 2D images of99mTc sestamibi distribution in the breast. Molecular breast tomosynthesis (MBT) maps the tracer distribution in 3D by acquiring multiple projections over a limited angular range. Here, the authors compare the performance of the two technologies in terms of spatial resolution, lesion contrast, and contrast‐to‐noise ratio (CNR) in phantom studies under conditions of clinically relevant sestamibi dose and imaging time.MethodsThe systems tested were a Dilon 6800 and a MBT prototype developed at the University of Virginia. Both systems comprise a pixelated sodium iodide scintillator, an array of position sensitive photomultipliers, and a parallel hole collimator. The active areas and energy resolution of the systems are similar. System sensitivity, spatial resolution, lesion contrast, and CNR were measured using a Petri dish, a point source phantom, and a breast phantom containing simulated lesions at two depths, respectively. A single BSGI projection was acquired. Five MBT projections were acquired over ±20°. For both modalities, the total scan count density was comparable to that observed for each in typical 10 min human scans following injection of 22 mCi (814 MBq) of99mTc‐sestamibi. To assess the impact of reducing the tracer dose, the pixel counts of projection images were later binomially subsampled by a factor of 2 to give images corresponding to an injected activity of approximately 11 mCi (407 MBq). Both unprocessed (pixelated) BSGI projections and interpolated (smoothed) BSGI images displayed by default on the Dilon 6800 workstation were analyzed. Volumetric images were reconstructed from the MBT projections using a maximum likelihood expectation maximization algorithm and extracted slices were analyzed.ResultsOver a depth range of 1.5–7.5 cm, BSGI spatial resolution was 5.6–11.5 mm in unprocessed projections and 5.7–12.0 mm in interpolated images. Over the same range, the in‐slice MBT spatial resolution was 6.7–9.4 mm. Lesion contrast was significantly improved with MBT relative to BSGI for five out of eight lesions imaged at either the 22 mCi or the 11 mCi dose level (p< 0.05). At both dose levels, significant improvements in CNR with MBT were also found for five out of eight lesions (9.8, 7.8, 6.2 mm lesions at water depth of 1.7 cm and 9.8, 7.8 mm lesions at water depth of 4.5 cm,p< 0.05). The 6.2 and 4.9 mm lesions located at 4.5 cm below the water surface were not visible in either modality at either activity level.ConclusionsUnder conditions of equal dose, imaging time and similar detectors, compared to BSGI, MBT provided higher lesion contrast, higher CNR, and spatial resolution that was less depth dependent.
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99mTc-MIBI 闪烁乳房X线照相术与动态MRI对比用于乳腺肿块的非侵入性表征
DOI：
--
发表时间：
2001
期刊：
European Journal of Nuclear Medicine
影响因子：
--
作者：
M. Imbriaco;S. Del Vecchio;A. Riccardi;L. Pace;F. Di Salle;F. Di Gennaro;M. Salvatore;A. Sodano
通讯作者：
A. Sodano
双模态乳房断层合成。
影响因子：
19.7
作者：
Williams,MarkB;Judy,PatriciaG;Gunn,Spencer;Majewski,Stanislaw
通讯作者：
Majewski,Stanislaw
DOI：
10.1093/jnci/92.13.1081
发表时间：
2000-07-05
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Mandelson, MT;Oestreicher, N;White, E
通讯作者：
White, E
准直器选择对专用核乳腺成像系统肿瘤检测的影响
影响因子：
1.8
作者：
C. Hruska;M. O’Connor
通讯作者：
M. O’Connor
影响因子：
3.8
作者：
M. O’Connor;G. Tourassi;C. Orton
通讯作者：
C. Orton