Cognitive and Structural Correlates of Conversational Speech Timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: Relevance for Early Detection Approaches.
Cognitive and Structural Correlates of Conversational Speech Timing in Mild Cognitive Impairment and Mild-to-Moderate Alzheimer's Disease: Relevance for Early Detection Approaches.
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DOI：
10.3389/fnagi.2021.637404
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发表时间：
2021
影响因子：
4.8
通讯作者：
Reilly RB
中科院分区：
文献类型：
--
作者：
De Looze C;Dehsarvi A;Crosby L;Vourdanou A;Coen RF;Lawlor BA;Reilly RB
背景资料：越来越多的努力集中在建立新的生物标志物，用于早期检测阿尔茨海默病（AD）和预测轻度认知障碍（MCI）向AD的转化。在健康老龄化过程中，在疾病发作和疾病进展期间的行为变化，最近已被提出作为检测MCI和AD的有希望的标志物。本研究探讨是否在协作参考任务的语音的时间特性与认知功能和体积的大脑区域参与语音生产和已知的MCI和AD病理减少。然后，我们探讨了区分能力的时间语音措施MCI和AD的分类。方法：MCI、轻度至中度AD和健康对照（HC）的个体接受了结构MRI扫描和一系列神经心理学测试。他们还参与了与护理人员的协作参考任务。通过线性混合效应模型研究了会话语音时间特征、认知功能（特定领域）和区域脑容量之间的关联。采用遗传程序设计方法研究了会话语音特征的识别能力。结果如下：MCI和轻度至中度AD的特征在于言语的一般缓慢，归因于较慢的语速和较慢的会话设置中的话轮转换。言语特征似乎反映了情景、词汇语义、执行功能和视觉空间缺陷以及额叶、颞叶和小脑区域的潜在体积减少。结论：在临床和社区环境中实施基于会话语音计时的技术可以为早期检测与MCI和AD相关的认知缺陷和结构变化提供额外的标记。
Background: Increasing efforts have focused on the establishment of novel biomarkers for the early detection of Alzheimer’s disease (AD) and prediction of Mild Cognitive Impairment (MCI)-to-AD conversion. Behavioral changes over the course of healthy ageing, at disease onset and during disease progression, have been recently put forward as promising markers for the detection of MCI and AD. The present study examines whether the temporal characteristics of speech in a collaborative referencing task are associated with cognitive function and the volumes of brain regions involved in speech production and known to be reduced in MCI and AD pathology. We then explore the discriminative ability of the temporal speech measures for the classification of MCI and AD. Method: Individuals with MCI, mild-to-moderate AD and healthy controls (HCs) underwent a structural MRI scan and a battery of neuropsychological tests. They also engaged in a collaborative referencing task with a caregiver. The associations between the conversational speech timing features, cognitive function (domain-specific) and regional brain volumes were examined by means of linear mixed-effect modeling. Genetic programming was used to explore the discriminative ability of the conversational speech features. Results: MCI and mild-to-moderate AD are characterized by a general slowness of speech, attributed to slower speech rate and slower turn-taking in conversational settings. The speech characteristics appear to be reflective of episodic, lexico-semantic, executive functioning and visuospatial deficits and underlying volume reductions in frontal, temporal and cerebellar areas. Conclusion: The implementation of conversational speech timing-based technologies in clinical and community settings may provide additional markers for the early detection of cognitive deficits and structural changes associated with MCI and AD.
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DOI：
10.1093/brain/awt269
发表时间：
2013-12
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Ahmed S;Haigh AM;de Jager CA;Garrard P
通讯作者：
Garrard P
影响因子：
2.6
作者：
Deschamps, Isabelle;Baum, Shari R.;Gracco, Vincent L.
通讯作者：
Gracco, Vincent L.
影响因子：
2.1
作者：
De Looze, Celine;Kelly, Finnian;Reilly, Richard B.
通讯作者：
Reilly, Richard B.
DOI：
10.1016/j.cortex.2012.03.001
发表时间：
2013-03
期刊：
Cortex; a journal devoted to the study of the nervous system and behavior
影响因子：
--
作者：
Baldo JV;Arévalo A;Patterson JP;Dronkers NF
通讯作者：
Dronkers NF
影响因子：
11.2
作者：
Chan, D;Fox, NC;Rossor, MN
通讯作者：
Rossor, MN