Localization of sites of enhanced expression of endothelin-1 in the kidney of DOCA-salt hypertensive rats.
Localization of sites of enhanced expression of endothelin-1 in the kidney of DOCA-salt hypertensive rats.
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DOCA-盐高血压大鼠肾脏内皮素-1 表达增强位点的定位。
DOI：
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发表时间：
1996
影响因子：
13.6
通讯作者：
E. Schiffrin
中科院分区：
文献类型：
--
作者：
L. Deng;R. Day;E. Schiffrin
Although the role of endothelin-1, a potent vasoconstrictor peptide, in hypertension remains unclear, there is evidence of its involvement in deoxycorticosterone acetate (DOCA)-salt hypertensive rats, in which enhanced vascular production of endothelin-1 has been documented. The study presented here examined endothelin-1 gene expression in the kidney in DOCA-salt hypertensive rats by in situ hybridization histochemistry. A high specific activity 35S-labeled complementary RNA probe was used. Significant increases in abundance of endothelin-1 mRNA transcripts were found in the endothelium of renal vessels, and in capillary endothelial and mesangial cells of glomeruli of the remaining kidney of DOCA-salt hypertensive rats, in comparison with unilaterally nephrectomized control rats. Enhanced expression of the endothelin-1 gene in the kidney of DOCA-salt hypertensive rats may participate in abnormalities of renal function in this model of hypertension, and thus contribute to the development and maintenance of elevated blood pressure.
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DOI：
10.1210/mend.6.3.1316544
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期刊：
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DOI：
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DOI：
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影响因子：
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DOI：
10.1152/ajprenal.1991.260.6.f913
发表时间：
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期刊：
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影响因子：
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