Association between white matter hyperintensity volume and social functioning limitations among stroke survivors.
Association between white matter hyperintensity volume and social functioning limitations among stroke survivors.
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DOI：
10.1016/j.jstrokecerebrovasdis.2022.106720
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发表时间：
2022-10
期刊：
影响因子：
--
通讯作者：
Rist PM
中科院分区：
文献类型：
--
作者：
Chang FG;Rost NS;Manson JE;Buring JE;Rist PM
现有的关于卒中患者白色高信号体积（WMHV）的文献很少关注与社会功能限制相关的卒中后结局，如交通、社交、食物准备、杂货店购物和家务。使用来自维生素D和OmegA-3 TriaL（VITAL）研究的前瞻性数据，我们评估了151例缺血性卒中患者中WMHV和社会功能限制之间的相关性。使用经验证的半自动化方法从卒中事件发生时收集的磁共振成像（MRI）中确定WMHV，并使用MRI扫描日期后中位数为1.25年的卒中结局问卷评估社会功能限制。采用Logistic回归分析探讨WMHV与社会功能限制之间的关系。在调整年龄和性别后，发现WMHV与社会交往限制之间存在统计学显著相关性（OR = 2.82; 95%CI：1.21 - 7.55）。与食物准备（OR = 2.06; 95%CI：0.99 - 4.54）、交通（OR = 1.39; 95%CI：0.85 - 2.27）和家务（OR = 1.37; 95%CI：0.91 - 2.11）相关的限制风险增加;然而，相关性未达到统计学显著性。我们没有观察到WMHV和杂货店购物限制之间的关联（OR = 1.08; 95%CI：0.61 - 1.89）。未来的研究需要进一步探索与社会互动限制之间关系的生物学机制，并使用更大，更多样化的研究样本复制我们的发现。
Existing literature on white matter hyperintensity volume (WMHV) in stroke patients has rarely focused on post-stroke outcomes related to social functioning limitations, such as transportation, social interaction, food preparation, grocery shopping, and housekeeping. Using prospective data from the VITamin D and OmegA-3 TriaL (VITAL) study, we evaluated the association between WMHV and social functioning limitations among 151 ischemic stroke patients. WMHV was ascertained from magnetic resonance imaging (MRI) collected at the time of the stroke event using a validated semiautomated method, and social functioning limitations were assessed using a stroke outcomes questionnaire administered a median of 1.25 years after the date of the MRI scan. Logistic regression was used to explore the association between WMHV and social functioning limitations. After adjusting for age and sex, a statistically significant association was found between WMHV and limitations in social interaction (OR=2.82; 95% CI: 1.21–7.55). Increased risks were seen for limitations related to food preparation (OR=2.06; 95% CI: 0.99–4.54), transportation (OR=1.39; 95% CI: 0.85–2.27), and housekeeping (OR=1.37; 95% CI: 0.91–2.11); however, the associations did not reach statistical significance. We observed no association between WMHV and limitations in grocery shopping (OR=1.08; 95% CI: 0.61–1.89). Future studies are needed to further explore the biological mechanisms underlying the relationship with limitations in social interaction and to replicate our findings using a larger and more diverse study sample.
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2.4
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