Protective Role of Rheumatic Diseases Against Hepatitis B Virus Infection and Human Leukocyte Antigen B27 Highlighted.
Protective Role of Rheumatic Diseases Against Hepatitis B Virus Infection and Human Leukocyte Antigen B27 Highlighted.
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DOI：
10.3389/fmed.2022.814423
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发表时间：
2022
影响因子：
3.9
通讯作者：
Han Y
中科院分区：
文献类型：
--
作者：
Ye J;Xie P;Zhou Z;Sun Y;Wang F;You Y;Teng J;Yang C;Zhang X;Han Y
通过测定风湿病患者暴露后乙型肝炎病毒（HBV）表面抗原（HBsAg）阳性率和乙型肝炎病毒特异性抗原/抗体（Ag/Ab）水平，我们旨在探讨风湿病与乙型肝炎控制的联系。纳入2020年至2021年在瑞金医院接受乙型肝炎筛查的患者进行暴露率估计。在乙型肝炎核心抗原（HBcAb）抗体阳性患者中，我们采用倾向评分匹配（PSM）来研究风湿病对暴露后HBsAg血清阳性率的影响。第二个 PSM 评估了 Ag/Ab 差异。我们还研究了人类白细胞抗原 B2 (HLA-B27) 测试患者的 HBsAg 患病率。在 33,989 名接受筛查的患者中，风湿病和非风湿病患者的暴露率仍然相当：48.94% vs. 49.86%。 PSM 首先产生 2,618 个平衡对。我们观察到 HBsAg 阳性病例中患有风湿性疾病的患者明显少于阴性病例 (p < 0.001)。在第二轮中，PSM匹配了279对，风湿病患者的HBsAg（p < 0.001）和HBeAg（p < 0.05）阳性率显着较低，而HBsAb阳性率（p < 0.001）和水平（p < 0.01）显着较高。尽管 HBcAb 的值在风湿性疾病领域总体显着较低 (p < 0.001)，但强直性脊柱炎 (AS) 患者的值明显高于其他风湿性疾病患者。我们发现 HLA-B27 阳性受试者的 HBV 感染明显少于阴性受试者 (p < 0.001)。在这项倾向评分匹配研究中，风湿病患者在乙肝控制方面具有优势。在风湿病患者中，HBcAb 水平以及 HLA-B27 的有益作用得到了强调。
By determining the hepatitis B virus (HBV) surface antigen (HBsAg) positive rate postexposure and HBV-specific antigen/antibody (Ag/Ab) level in patients with rheumatic diseases, we aimed at exploring the rheumatic link to HBV control. Patients who underwent HBV screening in the Ruijin Hospital from 2020 to 2021 were enrolled for the exposure rate estimation. Among antibody to HBV core antigen (HBcAb)-positive patients, we adopted propensity score matching (PSM) to study the impact of rheumatism on HBsAg seroprevalence after exposure. A second PSM evaluated the Ag/Ab differences. We also had HBsAg prevalence in human leukocyte antigen B2 (HLA-B27) tested patients studied. With 33,989 screened patients, exposure rates remained comparable between rheumatic and non-rheumatic patients: 48.94 vs. 49.86%. PSM first yielded 2,618 balanced pairs. We observed significantly fewer patients with rheumatic diseases in HBsAg positive cases than negative ones (p < 0.001). In the second round, PSM matched 279 pairs, HBsAg (p < 0.001) and HBeAg (p < 0.05) positivity rates were significantly lower in the rheumatic patients, whereas HBsAb positivity rate (p < 0.001) and level (p < 0.01) were significantly higher. Though the value of HBcAb was overall significantly lower (p < 0.001) within the realm of rheumatic diseases, patients with ankylosing spondylitis (AS) demonstrated a significantly higher value than other rheumatic diseases. We saw significantly fewer HBV infections in HLA-B27 positive subjects than in the negative ones (p < 0.001). In this propensity score-matched study, rheumatic patients had an advantage in HBV control. In rheumatic patients, HBcAb levels, together with the beneficial role of HLA-B27, were highlighted.
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影响因子：
6.4
作者：
Di Bona, Danilo;Pandey, Janardan P.;Accardi, Giulia
通讯作者：
Accardi, Giulia
影响因子：
30.8
作者：
Hu, Zhibin;Liu, Yao;Shen, Hongbing
通讯作者：
Shen, Hongbing
影响因子：
25.7
作者：
Le Bert, Nina;Salimzadeh, Loghman;Bertoletti, Antonio
通讯作者：
Bertoletti, Antonio
DOI：
10.1002/art.40320
发表时间：
2017-12
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Lundberg IE;Tjärnlund A;Bottai M;Werth VP;Pilkington C;de Visser M;Alfredsson L;Amato AA;Barohn RJ;Liang MH;Singh JA;Aggarwal R;Arnardottir S;Chinoy H;Cooper RG;Dankó K;Dimachkie MM;Feldman BM;Garcia-De La Torre I;Gordon P;Hayashi T;Katz JD;Kohsaka H;Lachenbruch PA;Lang BA;Li Y;Oddis CV;Olesinska M;Reed AM;Rutkowska-Sak L;Sanner H;Selva-O'Callaghan A;Song YW;Vencovsky J;Ytterberg SR;Miller FW;Rider LG;International Myositis Classification Criteria Project Consortium, the Euromyositis Register, and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland)
通讯作者：
International Myositis Classification Criteria Project Consortium, the Euromyositis Register, and the Juvenile Dermatomyositis Cohort Biomarker Study and Repository (UK and Ireland)
DOI：
10.1002/art.39859
发表时间：
2017-01
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Shiboski CH;Shiboski SC;Seror R;Criswell LA;Labetoulle M;Lietman TM;Rasmussen A;Scofield H;Vitali C;Bowman SJ;Mariette X;International Sjögren's Syndrome Criteria Working Group
通讯作者：
International Sjögren's Syndrome Criteria Working Group