Ligature-induced peri-implantitis and periodontitis in mice.
Ligature-induced peri-implantitis and periodontitis in mice.
复制标题
结扎诱导的小鼠植入物炎和牙周炎。
DOI：
10.1111/jcpe.12817
复制
发表时间：
2018-01
影响因子：
6.7
通讯作者：
Pirih FQ
中科院分区：
文献类型：
--
作者：
Hiyari S;Wong RL;Yaghsezian A;Naghibi A;Tetradis S;Camargo PM;Pirih FQ
植入术（PI），牙科周围的炎症与牙周炎（PD）共享，PI更难控制，治疗和详细的病理生理学。
雄性C57BL/6J小鼠将其左上颌磨牙置于加热的提取插座中，并将其扎在植入物周围和第二磨牙。进行骨损失分析的月份和三个月（n≥5/组/时间点）。耐strate抗性酸性磷酸酶（TRAP），基质金属蛋白酶8（MMP-8），活化B细胞（NF-κB）的核因子kappa-light-light-chain-chain-Enhancer，甲甲苯胺蓝和钙牛。
在三个月时，PI与PD相比，骨质损失更大，PI exfore的骨骼中有20％的骨骼损失。与PD相比，PI的破骨细胞，MMP-8和NF-κB增加。
与PD相比，PI暴露了更大的组织和骨骼破坏。
Peri-implantitis (PI), inflammation around dental implants, shares characteristics with periodontitis (PD). However, PI is more difficult to control, treat, and detailed pathophysiology is unclear. We aimed to compare PI and PD progression utilizing a murine model. Four-week-old male C57BL/6J mice had their left maxillary molars extracted. Implants were placed in healed extraction sockets and osseointegrated. Ligatures were tied around the implant and second molar. Controls did not receive ligatures. Mice were sacrificed one week, one month, and three months (n≥5/group/time point) post ligature placement. Bone loss analysis was performed. Histology was performed for: hematoxylin and eosin (H&E), Tartrate Resistant Acid Phosphatase (TRAP), matrix metalloproteinase-8 (MMP-8), nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), toluidine blue, and calcein. PI showed statistically greater bone loss compared to PD at one and three months. At three months, 20% of implants in PI exfoliated; no natural teeth exfoliated in PD. H&E revealed that alveolar bone surrounding implants in PI appeared less dense compared to PD. PI presented with increased osteoclasts, MMP-8, and NF-κB, compared to PD. PI exhibited greater tissue and bone destruction compared to PD. Future studies will characterize the pathophysiological differences between the two conditions.
登录
查看更多内容
DOI：
10.1097/med.0000000000000321
发表时间：
2017-04
期刊：
Current opinion in endocrinology, diabetes, and obesity
影响因子：
--
作者：
Attie AD;Churchill GA;Nadeau JH
通讯作者：
Nadeau JH
DOI：
10.2174/1874210601408010050
发表时间：
2014
期刊：
The open dentistry journal
影响因子：
--
作者：
Abraham CM
通讯作者：
Abraham CM
影响因子：
4.3
作者：
Chaichanasakul T;Kang B;Bezouglaia O;Aghaloo TL;Tetradis S
通讯作者：
Tetradis S
影响因子：
2.6
作者：
Basdra, EK;Komposch, G
通讯作者：
Komposch, G
影响因子：
6.7
作者：
Berglundh, Tord;Zitzmann, Nicola U.;Donati, Mauro
通讯作者：
Donati, Mauro