Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans.
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DOI：
10.1371/journal.pone.0028835
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Shen ZY
中科院分区：
文献类型：
--
作者：
Cai WJ;Huang JH;Zhang SQ;Wu B;Kapahi P;Zhang XM;Shen ZY
延缓衰老的化合物也可能延缓与年龄有关的疾病，延长人类的健康寿命。淫羊藿苷是从淫羊藿科的几种植物中提取的黄酮醇。淫羊藿苷及其代谢衍生物已被证明在与年龄相关的疾病中发挥广泛的保护作用。然而，淫羊藿苷及其衍生物是否具有延缓衰老的功效尚不清楚。本文报道淫羊藿苷及其衍生物淫羊藿苷II是C. elegans寿命。采用HPLC法检测淫羊藿苷处理的动物体内淫羊藿苷II的含量，结果表明淫羊藿苷II是淫羊藿苷在动物体内的活性形式。淫羊藿苷II还增加了热和氧化应激耐受性，减缓了成年后期的运动衰退，并延迟了polyQ和Aβ1-42蛋白毒性介导的瘫痪的发生。淫羊藿苷II的寿命延长作用依赖于胰岛素/IGF-1信号传导（IIS），因为daf-16（mu 86）和daf-2（e1370）在淫羊藿苷II治疗后未能显示任何寿命延长。因此，淫羊藿苷II处理上调野生型中的β-16靶标的表达。此外，我们的数据表明，热休克转录因子HSF-1在淫羊藿苷II依赖的寿命延长中发挥作用，进一步暗示IIS途径。总之，我们证明了一种新的天然化合物，淫羊藿苷II作为淫羊藿苷的生物活性形式，通过IIS途径延长了C.优雅
Compounds that delay aging might also postpone age-related diseases and extend healthspan in humans. Icariin is a flavonol extracted from several plant species of the Epimedium family. The icariin and its metabolic derivatives have been shown to exert wide protective effects in age-related diseases. However, whether icariin and its derivatives have the potency of delaying aging remains unclear. Here, we report that icariin and its derivative icariside II extend C. elegans lifespan. Using HPLC, we found high level of icariside II in the animals treated with icariin, suggesting icariside II is the bioactive form in vivo of icariin. Icariside II also increased the thermo and oxidative stress tolerance, slowed locomotion decline in late adulthood and delayed the onset of paralysis mediated by polyQ and Aβ1–42 proteotoxicity. The lifespan extension effect of icariside II is dependent on the insulin/IGF-1 signaling (IIS) since the daf-16(mu86) and daf-2(e1370) failed to show any lifespan extension upon icariside II treatment. Consistently, icariside II treatment upregulates the expression of DAF-16 targets in the wild-type. Moreover, our data suggests that the heat shock transcription factor HSF-1 has a role in icariside II-dependent lifespan extension further implicating the IIS pathway. In conclusion, we demonstrate a novel natural compound, icariside II as the bioactive form of icariin, extends the healthspan via IIS pathway in C. elegans.
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影响因子：
7.8
作者：
Ching TT;Paal AB;Mehta A;Zhong L;Hsu AL
通讯作者：
Hsu AL
DOI：
10.1016/j.jpba.2004.06.021
发表时间：
2004-10-29
影响因子：
3.4
作者：
Liu, J;Lou, YJ
通讯作者：
Lou, YJ
影响因子：
64.8
作者：
Herndon, LA;Schmeissner, PJ;Driscoll, M
通讯作者：
Driscoll, M
影响因子：
29
作者：
Kapahi P;Chen D;Rogers AN;Katewa SD;Li PW;Thomas EL;Kockel L
通讯作者：
Kockel L
DOI：
10.1073/pnas.95.22.13091
发表时间：
1998-10-27
影响因子：
11.1
作者：
Lakowski, B;Hekimi, S
通讯作者：
Hekimi, S