Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery.
Effect of formulation pH on transport of naltrexone species and pore closure in microneedle-enhanced transdermal drug delivery.
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DOI：
10.1021/mp3007083
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发表时间：
2013-06-03
影响因子：
4.9
通讯作者：
Stinchcomb AL
中科院分区：
文献类型：
--
作者：
Ghosh P;Brogden NK;Stinchcomb AL
针头增强的经皮给药极大地改善了可通过皮肤转运的生物活性分子的亚类。制剂pH值在所有药物递送系统中起着重要作用;然而，对于透皮递送，其变得特别重要，因为只要不导致皮肤刺激或致敏问题，就可以将宽范围的pH值用于贴剂制剂。伤口愈合文献显示pH值对屏障恢复有显著影响。药物的稳定性和溶解度，从而通过皮肤的运输都受到制剂pH值的影响。目前的研究检查了药物纳曲酮的电离状态对微针治疗皮肤的经皮通量和渗透性的作用，与完整的皮肤相比。在猪体内进行阻抗谱分析，以评估在三种不同pH条件的影响下制剂pH对血管闭合速率的作用。数据表明，虽然使用较低pH的制剂在穿过微针处理的皮肤的总转运方面具有显著优势，但是pH在最初的24小时之后对血管闭合速率没有任何显著影响。
Microneedle-enhanced transdermal drug delivery greatly improves the subset of pharmacologically active molecules that can be transported across the skin. Formulation pH plays an important role in all drug delivery systems; however, for transdermal delivery it becomes specifically significant since a wide range of pH values can be exploited for patch formulation as long as it does not lead to skin irritation or sensitization issues. Wound healing literature has shown significant pH effects on barrier recovery. Stability and solubility of the drug, and thus transport across skin are all affected by formulation pH. The current study examined the role of ionization state of the drug naltrexone on transdermal flux and permeability across microneedle treated skin, as compared to intact skin. Impedance spectroscopy was done in pigs in vivo to assess the role of formulation pH on the rate of micropore closure under the influence of three different pH conditions. The data indicated that while there was significant advantage of using a lower pH formulation in terms of total transport across microneedle treated skin, the pH however did not have any significant effect on the rate of micropore closure beyond the first 24 hours.
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DOI：
10.1046/j.1523-1747.2002.19632.x
发表时间：
2002-12-01
影响因子：
--
作者：
Elias, PM;Tsai, J;Feingold, KR
通讯作者：
Feingold, KR
影响因子：
6.5
作者：
Feingold, Kenneth R.
通讯作者：
Feingold, Kenneth R.
影响因子：
3.7
作者：
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Banga, Ajay K.
影响因子：
5.4
作者：
Gupta, Jyoti;Felner, Eric I.;Prausnitz, Mark R.
通讯作者：
Prausnitz, Mark R.
影响因子：
3.2
作者：
Gomaa, Yasmine A.;Morrow, Desmond I. J.;Meidan, Victor M.
通讯作者：
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