Increased levels of serum interleukin-10 are associated with poor outcome in adult hemophagocytic lymphohistiocytosis patients.
Increased levels of serum interleukin-10 are associated with poor outcome in adult hemophagocytic lymphohistiocytosis patients.
复制标题
DOI：
10.1186/s13023-021-01973-4
复制
发表时间：
2021-08-04
影响因子：
3.7
通讯作者：
Li F
中科院分区：
文献类型：
--
作者：
Zhou Y;Kong F;Wang S;Yu M;Xu Y;Kang J;Tu S;Li F
白细胞介素-10 (IL-10) 是预测噬血细胞性淋巴组织细胞增多症 (HLH) 儿科患者不良结局的独立因素。然而，人们对其对成年患者的预后价值知之甚少。这项单中心回顾性研究旨在探讨 IL-10 对 101 名新诊断为 HLH 的成人的预后价值。使用细胞因子分析试剂盒通过化学发光定量测定血清白细胞介素水平。成年 HLH 患者血清 IL-10 水平显着升高。 IL-10水平升高与血红蛋白浓度降低相关（r = − 0.279，P = 0.005）。巨噬细胞活化综合征（MAS）患者的IL-10水平显着低于感染相关HLH（IAHS）和恶性肿瘤相关HLH（MAHS）患者（P = 0.033，P = 0.012）。 MAS患者的生存期比IAHS和MAHS患者相对较长（P<0.001）。单因素分析显示血红蛋白 < 8.2 g/dL，血小板 < 40 × 109/L，乳酸脱氢酶 ≥ 700 IU/L，白蛋白 < 28 g/L，治疗后铁蛋白 > 1050 µg/L， IL-10 ≥ 129 pg/mL 是生存的不良预后因素。然而，多变量分析显示，只有诊断时的高血清 IL-10 水平 (≥129 pg/mL) 和治疗后高铁蛋白水平 (>1050 µg/L) 是成人 HLH 患者总生存率较差的独立危险因素 (HR: 4.087，95% CI 2.064–8.090，P<0.001；HR 3.814, 95% CI 2.042–7.126, P < 0.001，分别）。我们的结果表明，较高的血清 IL-10 水平可能是成年 HLH 患者的预后标志。在线版本包含可在 10.1186/s13023-021-01973-4 获取的补充材料。
Interleukin-10 (IL-10) is an independent factor for predicting adverse outcomes in pediatric patients with hemophagocytic lymphohistiocytosis (HLH). However, little is known about its prognostic value in adult patients. This single center retrospective study was conducted to explore the prognostic value of IL-10 in 101 adults newly diagnosed with HLH. The serum interleukin levels were quantitatively determined by chemiluminescence using cytokine profiling kits. Serum IL-10 levels were significantly increased in adult HLH patients. Elevated IL-10 levels was correlated with lower concentrations of hemoglobin (r = − 0.279, P = 0.005). IL-10 levels were significantly lower in patients with macrophage activation syndrome (MAS) than in those with infection-associated HLH (IAHS) and malignancy-associated HLH (MAHS) (P = 0.033, P = 0.012). Patients with MAS had relatively longer survival than those with IAHS and MAHS (P < 0.001). Univariate analysis indicated that hemoglobin < 8.2 g/dL, platelets < 40 × 109/L, lactate dehydrogenase ≥ 700 IU/L, albumin < 28 g/L, post-treatment ferritin > 1050 µg/L and IL-10 ≥ 129 pg/mL were poor prognostic factors for survival. However, multivariate analysis revealed that only high serum IL-10 levels (≥ 129 pg/mL) at diagnosis and high post-treatment ferritin levels (> 1050 µg/L) were independent risk factors for poor overall survival in adult HLH patients (HR: 4.087, 95% CI 2.064–8.090, P < 0.001; HR 3.814, 95% CI 2.042–7.126, P < 0.001, respectively). Our results suggest that higher serum IL-10 levels might be a prognostic marker in adult HLH patients. The online version contains supplementary material available at 10.1186/s13023-021-01973-4.
登录
查看更多内容
影响因子：
3.5
作者：
Bin, Qiong;Gao, Jin-Hong;Luo, Jian-Ming
通讯作者：
Luo, Jian-Ming
影响因子：
1.3
作者：
Iyer SS;Cheng G
通讯作者：
Cheng G
DOI：
10.1007/978-94-024-0921-5_5
发表时间：
2016-01-01
期刊：
REGULATION OF CYTOKINE GENE EXPRESSION IN IMMUNITY AND DISEASES
影响因子：
--
作者：
Rutz, Sascha;Ouyang, Wenjun
通讯作者：
Ouyang, Wenjun
影响因子：
6.5
作者：
Tang, Yongmin;Xu, Xiaojun;Luo, Chunfang
通讯作者：
Luo, Chunfang
影响因子：
20.3
作者：
Osugi, Y;Hara, J;Tawa, A
通讯作者：
Tawa, A