Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa.
Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa.
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DOI：
10.3390/ijms22094943
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发表时间：
2021-05-06
影响因子：
5.6
通讯作者：
Schiavetti F
中科院分区：
文献类型：
--
作者：
Antonelli G;Cappelli L;Cinelli P;Cuffaro R;Manca B;Nicchi S;Tondi S;Vezzani G;Viviani V;Delany I;Scarselli M;Schiavetti F
传统的抗菌治疗包括针对病原体中不同基本功能的药物。尽管如此，细菌仍在不断进化新的机制来逃避这种药物介导的杀伤，在全球范围内部署每种新药和抗生素的速度令人惊讶，这种现象称为抗菌素耐药性（AMR）。如今，AMR是一种严重的健康威胁，迫切需要新的医疗干预措施。到2050年，估计死亡的主要原因将是无法治疗的AMR病原体。虽然抗生素仍然是一线治疗，但非抗生素疗法如预防性疫苗和治疗性单克隆抗体（mAb）是限制此类抗生素耐药微生物传播的越来越令人感兴趣的替代方案。为了发现新的疫苗和单克隆抗体，寻找能够提高保护性免疫应答的有效抗原是一项具有挑战性的工作。在这种情况下，外膜囊泡（OMV）代表了一种有前途的方法，因为它们概括了革兰氏阴性菌表面上发生的完整抗原库。在这篇综述中，我们提出了大肠杆菌和铜绿假单胞菌作为革兰氏阴性菌引起的AMR威胁的具体例子，我们讨论了目前的单克隆抗体和疫苗的方法正在开发中，以及如何对OMV的知识可能有利于抗原发现策略。
Traditional antimicrobial treatments consist of drugs which target different essential functions in pathogens. Nevertheless, bacteria continue to evolve new mechanisms to evade this drug-mediated killing with surprising speed on the deployment of each new drug and antibiotic worldwide, a phenomenon called antimicrobial resistance (AMR). Nowadays, AMR represents a critical health threat, for which new medical interventions are urgently needed. By 2050, it is estimated that the leading cause of death will be through untreatable AMR pathogens. Although antibiotics remain a first-line treatment, non-antibiotic therapies such as prophylactic vaccines and therapeutic monoclonal antibodies (mAbs) are increasingly interesting alternatives to limit the spread of such antibiotic resistant microorganisms. For the discovery of new vaccines and mAbs, the search for effective antigens that are able to raise protective immune responses is a challenging undertaking. In this context, outer membrane vesicles (OMV) represent a promising approach, as they recapitulate the complete antigen repertoire that occurs on the surface of Gram-negative bacteria. In this review, we present Escherichia coli and Pseudomonas aeruginosa as specific examples of key AMR threats caused by Gram-negative bacteria and we discuss the current status of mAbs and vaccine approaches under development as well as how knowledge on OMV could benefit antigen discovery strategies.
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影响因子：
168.9
作者：
Christensen, Kaare;Doblhammer, Gabriele;Rau, Roland;Vaupel, James W.
通讯作者：
Vaupel, James W.
影响因子：
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作者：
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通讯作者：
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影响因子：
5.3
作者：
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通讯作者：
Burrows, Lori L.
影响因子：
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作者：
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通讯作者：
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影响因子：
23.4
作者：
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通讯作者：
Schulman, CC