The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.
复制标题
DOI：
10.1371/journal.pone.0017063
复制
发表时间：
2011-02-16
期刊：
影响因子：
3.7
通讯作者：
Suarez-Kurtz G
中科院分区：
文献类型：
--
作者：
Pena SD;Di Pietro G;Fuchshuber-Moraes M;Genro JP;Hutz MH;Kehdy Fde S;Kohlrausch F;Magno LA;Montenegro RC;Moraes MO;de Moraes ME;de Moraes MR;Ojopi EB;Perini JA;Racciopi C;Ribeiro-Dos-Santos AK;Rios-Santos F;Romano-Silva MA;Sortica VA;Suarez-Kurtz G
基于前DNA种族/肤色方法学，临床和药理学试验传统上认为巴西不同的地理区域非常不同。我们希望确定这种地区色彩类别的多样性如何与祖先相关。使用一组由40个有效的祖先信息插入-缺失DNA多态组成的小组，我们分别估计了来自巴西人口最多的四个地区的934名自分类的白人、棕色或黑人巴西人的欧洲、非洲和美洲印第安人的祖先成分。我们揭示了不同地区之间和不同地区内部巨大的祖先多样性。特别是，巴西北部的颜色类别在祖先比例上与该国南部的颜色类别明显不同，这表明在自我分类中使用了不同的区域语义，如白色、棕色或黑色。为了绕过这些地区在颜色感知上的主观差异，我们以一种独立于颜色考虑的形式估计了四个地区中每一个地区的总体祖先比例。为此，我们将给定的祖先在给定的颜色类别中的比例乘以关于该颜色类别在特定地区的比例的官方人口普查信息，以得出“总祖先”的估计。一旦进行了这样的计算，出现的一致性水平比之前预期的要高得多。在所研究的所有地区，欧洲血统占主导地位，比例从东北部的60.6%到南部的77.7%不等。我们认为，19世纪和20世纪600万欧洲人移民到巴西--这一现象被描述为并打算被描述为“巴西的白化”--在很大程度上是导致先前反映特定地区人口历史的祖先差异消失的原因。这些发现对巴西具有临床和社会学意义，也应该适用于拥有祖先混血人口的其他国家。
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity of regional color categories correlated with ancestry. Using a panel of 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually the European, African and Amerindian ancestry components of 934 self-categorized White, Brown or Black Brazilians from the four most populous regions of the Country. We unraveled great ancestral diversity between and within the different regions. Especially, color categories in the northern part of Brazil diverged significantly in their ancestry proportions from their counterparts in the southern part of the Country, indicating that diverse regional semantics were being used in the self-classification as White, Brown or Black. To circumvent these regional subjective differences in color perception, we estimated the general ancestry proportions of each of the four regions in a form independent of color considerations. For that, we multiplied the proportions of a given ancestry in a given color category by the official census information about the proportion of that color category in the specific region, to arrive at a “total ancestry” estimate. Once such a calculation was performed, there emerged a much higher level of uniformity than previously expected. In all regions studied, the European ancestry was predominant, with proportions ranging from 60.6% in the Northeast to 77.7% in the South. We propose that the immigration of six million Europeans to Brazil in the 19th and 20th centuries - a phenomenon described and intended as the “whitening of Brazil” - is in large part responsible for dissipating previous ancestry dissimilarities that reflected region-specific population histories. These findings, of both clinical and sociological importance for Brazil, should also be relevant to other countries with ancestrally admixed populations.
登录
查看更多内容
影响因子：
1.5
作者：
Carvalho-Silva, DR;Tarazona-Santos, E;Santos, FR
通讯作者：
Santos, FR
DOI：
10.1590/s0100-879x2009005000026
发表时间：
2009-10-01
影响因子：
2.3
作者：
Pena, S.D.J.;Bastos-Rodrigues, L.;Bydlowski, S.P.
通讯作者：
Bydlowski, S.P.
DOI：
10.1073/pnas.0126614100
发表时间：
2003-01-07
影响因子：
11.1
作者：
Parra, FC;Amado, RC;Pena, SDJ
通讯作者：
Pena, SDJ
影响因子：
9.8
作者：
Alves-Silva, J;Santos, MD;Prado, VF
通讯作者：
Prado, VF
影响因子：
1.8
作者：
Pimenta, Juliana R.;Zuccherato, Luciana W.;Pena, Sergio D. J.
通讯作者：
Pena, Sergio D. J.