Different roles of cytoarchitectonic BA 44 and BA 45 in phonological and semantic verbal fluency as revealed by dynamic causal modelling.
Different roles of cytoarchitectonic BA 44 and BA 45 in phonological and semantic verbal fluency as revealed by dynamic causal modelling.
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DOI：
10.1016/j.neuroimage.2009.06.044
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发表时间：
2009-11-15
期刊：
影响因子：
5.7
通讯作者：
Amunts, Katrin
中科院分区：
文献类型：
--
作者：
Heim, Stefan;Eickhoff, Simon B.;Amunts, Katrin
使用动态因果模型 (DCM) 研究了语义和语音语言流利性任务中左细胞结构 BA 44 和 BA 45 的相互作用。测试了三种不同的模型，所有模型都将 BA 44 和 BA 45 作为自上而下驱动的互连节点，投射到运动皮层作为最终输出区域。模型 #1 表示这样的假设：BA 45 参与词汇检索，包括语义和语音过程，而 BA 44 支持其他语音过程。模型 #2 反映了 BA 44（语音处理）和 BA 45（语义处理）所维持的计算过程的明确分离的概念。模型 #3 基于 BA 44 和 BA 45 都支持语义和语音处理的假设。当通过贝叶斯模型选择对这些模型进行比较时，出现了支持第一个模型的证据，这意味着 BA 45 支持单词检索过程，而 BA 44 参与在单词生成过程中处理语音信息。在模型 #1 的导出模型参数的后续分析中，除了 BA 44 和 BA 45 之间的抑制耦合外，所有连接强度均显着为正。这种抑制可能反映了 BA 44 在单词生成过程中的语音分析如何限制 BA 45 中的词汇检索。总而言之，DCM 提供了关于 BA 44 和 BA 45 在言语流利度过程中的作用的更多见解，揭示了 BA 45 在词汇检索中的参与以及 BA 的相关性。 44 用于单词生成过程中的语音处理。
The interactions of left cytoarchitectonic BA 44 and BA 45 during semantic and phonological verbal fluency tasks were investigated using dynamic causal modelling (DCM). Three different models were tested, all of which featured BA 44 and BA 45 as top-down driven interconnected nodes projecting to the motor cortex as the final output region. Model #1 represents the hypothesis that BA 45 is involved in lexical retrieval including both semantic and phonological processes, while BA 44 supports other phonological processes. Model #2 reflects the notion of a clear-cut segregation of computational processes sustained by BA 44 (phonological processing) and BA 45 (semantic processing). Model #3 was based on the hypothesis that both BA 44 and BA 45 support semantic and phonological processing. When these models were compared against each other by Bayesian model selection, evidence emerged in favour of the first model, implying that BA 45 supports word retrieval processes whereas BA 44 is involved in processing phonological information during word generation. In a subsequent analysis of the derived model parameters for model #1, all connection strengths were significantly positive except for the inhibitory coupling between BA 44 and BA 45. This inhibition may reflect how the phonological analysis in BA 44 during word generation constrains lexical word retrieval in BA 45. To conclude, DCM provided additional insights into the roles of BA 44 and BA 45 during verbal fluency revealing the involvement of BA 45 in lexical retrieval and the relevance of BA 44 for phonological processing during word generation.
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