Association of serum vaspin and adiponectin levels with renal function in patients with or without type 2 diabetes mellitus.
Association of serum vaspin and adiponectin levels with renal function in patients with or without type 2 diabetes mellitus.
复制标题
患有或不患有 2 型糖尿病的患者血清 Vaspin 和脂联素水平与肾功能的关系
DOI：
10.1155/2014/868732
复制
发表时间：
2014
影响因子：
4.3
通讯作者：
Xu Y
中科院分区：
文献类型：
--
作者：
Yan M;Su B;Peng W;Li L;Li H;Zhuang J;Lu Y;Jian W;Wei Y;Li W;Qu S;Xu Y
Vaspin和脂联素是两种具有抗糖尿病作用的脂肪细胞因子。一些研究报道脂联素和vaspin水平与肾小球滤过率（FGR）降低和白蛋白尿增加相关。因此，我们评估了vaspin和脂联素水平在肾功能不全（RI）患者与T2DM或不。对416例2型糖尿病患者进行了血清vaspin、脂联素水平测定。根据这些受试者是否存在RI进行组间分析。我们发现，血清脂联素水平显着高于非糖尿病患者RI比非糖尿病患者无RI，但有RI和无RI的糖尿病患者之间没有统计学差异。在所有受试者中，50例RI患者的血清脂联素水平也高于366例非RI患者。血清vaspin水平在糖尿病患者和非糖尿病患者RI与无RI之间均无显著性差异。与脂联素相反，169例T2DM患者的血清vaspin水平低于247例非T2DM患者。提示血清脂联素水平与2型糖尿病及肾功能不全均相关。然而，血清vaspin水平在肾功能不全和无肾功能不全的个体之间没有显着差异。
Vaspin and adiponectin are two adipocytokines with antidiabetic effects. Some studies reported that levels of adiponectin and vaspin were correlated with decreased glomerular filtration rate (FGR) and increased albuminuria. We therefore evaluated the vaspin and adiponectin levels in renal insufficiency (RI) patients with or without T2DM. Serum vaspin, adiponectin levels were measured in 416 subjects with or without T2DM. Analysis was made between groups divided by these subjects presence or absence of RI. We found that serum adiponectin level was significantly higher in nondiabetic patients with RI than in nondiabetic subjects without RI; however, there were no statistical differences between the diabetic patients with RI and without RI. In all the subjects, the serum adiponectin level was also higher in 50 individuals with RI than that in 366 subjects without RI. The serum vaspin levels showed no significant differences between the diabetic patients or nondiabetics subjects with RI and without RI. Contrary to adiponectin, the serum vaspin level was lower in 169 patients with T2DM than in 247 individuals without T2DM. Our data suggested that both of T2DM and renal insufficiency were correlated with the serum level of adiponectin. However, the serum vaspin levels showed no significant difference between the individuals with renal insufficiency and without renal insufficiency.
登录
查看更多内容
影响因子：
12.3
作者：
Law RH;Zhang Q;McGowan S;Buckle AM;Silverman GA;Wong W;Rosado CJ;Langendorf CG;Pike RN;Bird PI;Whisstock JC
通讯作者：
Whisstock JC
影响因子：
2.3
作者：
Inoue J;Wada J;Teshigawara S;Hida K;Nakatsuka A;Takatori Y;Kojo S;Akagi S;Nakao K;Miyatake N;McDonald JF;Makino H
通讯作者：
Makino H
DOI：
10.2183/pjab.86.131
发表时间：
2010
期刊：
Proceedings of the Japan Academy. Series B, Physical and biological sciences
影响因子：
--
作者：
Matsuzawa Y
通讯作者：
Matsuzawa Y
影响因子：
4.9
作者：
McCourt, H. J.;Hunter, S. J.;McKinley, M. C.
通讯作者：
McKinley, M. C.
肿瘤坏死因子-α的脂肪表达--在与肥胖相关的胰岛素抵抗中的直接作用
影响因子：
56.9
作者：
HOTAMISLIGIL, GS;SHARGILL, NS;SPIEGELMAN, BM
通讯作者：
SPIEGELMAN, BM