The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial.
The Effects of Delayed Cord Clamping on 12-Month Brain Myelin Content and Neurodevelopment: A Randomized Controlled Trial.
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DOI：
10.1055/s-0040-1714258
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发表时间：
2022-01
影响因子：
2
通讯作者：
Padbury, James F.
中科院分区：
文献类型：
--
作者：
Mercer, Judith S.;Erickson-Owens, Debra A.;Deoni, Sean C. L.;Dean, Douglas C., III;Tucker, Richard;Parker, Ashley B.;Joelson, Sarah;Mercer, Emily N.;Collins, Jennifer;Padbury, James F.
本研究旨在确定延迟脊髓钳夹（DCC）是否影响足月儿脑髓鞘水体积分数矿物质（VFm）值和神经发育。这是一项单盲随机对照试验，在健康孕妇中进行，足月单胎胎儿在出生时随机接受立即脐带钳夹（ICC）（≤ 20秒）或DCC（≥ 5分钟）。12个月大时的随访包括血清铁指数和铅水平的血液检查，非镇静磁共振成像（MRI），随后在一周内进行神经发育测试。在出生时，73名妇女被随机分为两组：ICC（常规做法）或DCC（干预）。在12个月时，在58名活跃参与者中，41名（80%）有可用的MRI。两组之间在母亲或婴儿人口统计学变量上没有差异。在12个月时，患有DCC的婴儿在左右内囊、右顶叶、枕叶和前额叶皮质内的区域内的白色脑生长增加。性别对所有变量均无影响。发育测试（马伦早期学习量表、非语言和语言综合评分）在两组之间没有显著差异。在12个月大时，接受DCC的婴儿在参与运动功能，视觉/空间和感觉处理的重要脑区中有更大的髓鞘含量。出生时胎盘输血似乎增加了早期发育大脑中的髓鞘含量。
This study aimed to determine if delayed cord clamping (DCC) affected brain myelin water volume fraction mineral (VFm) value and neurodevelopment in term infants. This was a single-blinded randomized controlled trial of healthy pregnant women with term singleton fetuses randomized at birth to either immediate cord clamping (ICC) (≤ 20 seconds) or DCC (≥ 5 minutes). Follow-up at 12 months of age consisted of blood work for serum iron indices and lead levels, a nonsedated magnetic resonance imaging (MRI), followed within the week by neurodevelopmental testing. At birth, 73 women were randomized into one of two groups: ICC (the usual practice) or DCC (the intervention). At 12 months, among 58 active participants, 41 (80%) had usable MRIs. There were no differences between the two groups on maternal or infant demographic variables. At 12 months, infants who had DCC had increased white matter brain growth in regions localized within the right and left internal capsules, the right parietal, occipital, and prefrontal cortex. Gender exerted no difference on any variables. Developmental testing (Mullen Scales of Early Learning, nonverbal, and verbal composite scores) was not significantly different between the two groups. At 12 months of age, infants who received DCC had greater myelin content in important brain regions involved in motor function, visual/spatial, and sensory processing. A placental transfusion at birth appeared to increase myelin content in the early developing brain.
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DOI：
10.1111/j.1651-2227.1966.tb17659.x
发表时间：
1966-01-01
期刊：
ACTA PAEDIATRICA SCANDINAVICA
影响因子：
--
作者：
ARCILLA, RA;OH, W;GESSNER, IH
通讯作者：
GESSNER, IH
影响因子：
26.1
作者：
Andersson, Ola;Domellof, Magnus;Hellstrom-Westas, Lena
通讯作者：
Hellstrom-Westas, Lena
影响因子：
3.1
作者：
Deoni SC;O'Muircheartaigh J;Elison JT;Walker L;Doernberg E;Waskiewicz N;Dirks H;Piryatinsky I;Dean DC 3rd;Jumbe NL
通讯作者：
Jumbe NL
影响因子：
4.4
作者：
Deoni, Sean C. L.;Rutt, Brian K.;Jones, Derek K.
通讯作者：
Jones, Derek K.
影响因子：
3.1
作者：
Dean DC 3rd;O'Muircheartaigh J;Dirks H;Waskiewicz N;Walker L;Doernberg E;Piryatinsky I;Deoni SC
通讯作者：
Deoni SC