Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial.
Dose-Response of Aerobic Exercise on Cognition: A Community-Based, Pilot Randomized Controlled Trial.
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DOI：
10.1371/journal.pone.0131647
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Burns JM
中科院分区：
文献类型：
--
作者：
Vidoni ED;Johnson DK;Morris JK;Van Sciver A;Greer CS;Billinger SA;Donnelly JE;Burns JM
流行病学研究表明，体力活动和认知结果之间存在剂量反应关系。然而，没有来自随机试验的直接数据来支持这些间接观察结果。本研究旨在探讨有氧运动量对认知功能的影响。没有认知障碍的活动不足或久坐不动的参与者被随机分为四组：无变化对照组，每周75分钟，150分钟和225分钟的中等强度半监督有氧运动，持续26周。认知结果是来自16项认知测试的潜在残留分数：言语记忆，视觉空间处理，简单注意，集合维持和转移，推理。其他结果指标包括心肺适应性（峰值耗氧量）和功能健康指标。在意向治疗（ITT）分析（n = 101）中，4组的心肺适应性增加，感知残疾以剂量依赖性方式降低。在ITT分析中未观察到其他运动相关影响。分析仅限于个人行使按协议（n = 77）表明，简单注意力的改善等同于所有运动组相比，控制和剂量反应关系是目前的视觉空间处理。运动与心肺适能之间存在明显的剂量-反应关系。认知方面的益处在低剂量时很明显，在高剂量时视觉空间功能方面的益处可能会增加，但仅限于那些坚持运动方案的人。个体的心肺适能反应是比运动剂量更好的认知增益预测因子（即，持续时间），从而使个体的心肺适应性最大化可能是实现认知益处的重要治疗目标。ClinicalTrials.gov www.example.com
Epidemiological studies suggest a dose-response relationship exists between physical activity and cognitive outcomes. However, no direct data from randomized trials exists to support these indirect observations. The purpose of this study was to explore the possible relationship of aerobic exercise dose on cognition. Underactive or sedentary participants without cognitive impairment were randomized to one of four groups: no-change control, 75, 150, and 225 minutes per week of moderate-intensity semi-supervised aerobic exercise for 26-weeks in a community setting. Cognitive outcomes were latent residual scores derived from a battery of 16 cognitive tests: Verbal Memory, Visuospatial Processing, Simple Attention, Set Maintenance and Shifting, and Reasoning. Other outcome measures were cardiorespiratory fitness (peak oxygen consumption) and measures of function functional health. In intent-to-treat (ITT) analyses (n = 101), cardiorespiratory fitness increased and perceived disability decreased in a dose-dependent manner across the 4 groups. No other exercise-related effects were observed in ITT analyses. Analyses restricted to individuals who exercised per-protocol (n = 77) demonstrated that Simple Attention improved equivalently across all exercise groups compared to controls and a dose-response relationship was present for Visuospatial Processing. A clear dose-response relationship exists between exercise and cardiorespiratory fitness. Cognitive benefits were apparent at low doses with possible increased benefits in visuospatial function at higher doses but only in those who adhered to the exercise protocol. An individual’s cardiorespiratory fitness response was a better predictor of cognitive gains than exercise dose (i.e., duration) and thus maximizing an individual’s cardiorespiratory fitness may be an important therapeutic target for achieving cognitive benefits. ClinicalTrials.gov NCT01129115
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影响因子：
120.7
作者：
Church, Timothy S.;Earnest, Conrad P.;Blair, Steven N.
通讯作者：
Blair, Steven N.
DOI：
10.1249/01.mss.0000113738.06267.e5
发表时间：
2004-02-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Morss, GM;Jordan, AN;Blair, SN
通讯作者：
Blair, SN
影响因子：
--
作者：
Laurin, D;Verreault, R;Rockwood, K
通讯作者：
Rockwood, K
影响因子：
3.3
作者：
Bouchard, Claude;Sarzynski, Mark A.;Rankinen, Tuomo
通讯作者：
Rankinen, Tuomo
影响因子：
168.9
作者：
Gaziano, Thomas A.;Galea, Gauden;Reddy, K. Srinath
通讯作者：
Reddy, K. Srinath