3D‐isotropic high‐resolution morphological imaging and quantitative T2 mapping as biomarkers for gender related differences after matrix‐associated autologous chondrocyte transplantation (MACT)
3D‐isotropic high‐resolution morphological imaging and quantitative T2 mapping as biomarkers for gender related differences after matrix‐associated autologous chondrocyte transplantation (MACT)
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3D 各向同性高分辨率形态学成像和定量 T2 映射作为基质相关自体软骨细胞移植 (MACT) 后性别相关差异的生物标志物
DOI：
10.1002/jor.22682
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发表时间：
2014
影响因子：
2.8
通讯作者：
Welsch GH
中科院分区：
文献类型：
--
作者：
Pachowsky ML;Werner S;Marlovits S;Stelzeneder D;Renner N;Trattnig S;Welsch GH
本研究的目的是确定软骨修复组织（MACT）体内高分辨率形态学和生化相关的性别差异。对40例患者进行临床检查，并通过3T - MRI（冠状面3D True - FISP序列进行形态学评估，多回声自旋-回声T2 -定位进行健康软骨和MACT软骨的生化评估）扫描。深区修复组织平均T2值显示，女性T2时间明显短（p= 0.009，女性43.5±9.8 ms vs男性48.2±7.7 ms）。两组患者T2值均高于深部区（女性48.5±9.8 ms，男性52.6±11.0 ms），男女差异无统计学意义。原生对照软骨T2在女性和男性之间无统计学差异。MOCART评分中“修复组织结构”和“软骨下骨”细分，男女差异有统计学意义（p= 0.026和p= 0.007）， Lysholm评分差异有统计学意义（p= 0.03）。我们的研究揭示了膝关节MACT术后女性和男性患者在临床结果和高级形态学和生化MRI上的差异。所提出的成像生物标志物可以描述软骨再生手术后的细微变化，并可能有助于理解软骨修复手术后的性别差异。©2014骨科研究学会。Wiley期刊公司出版。[J]中华骨科杂志，2014。
The aim of this study was to determine in vivo high‐resolution morphological and biochemical gender related differences in cartilage repair tissue (MACT). Forty patients were examined clinically and by MR scans at 3T‐MRI (coronal 3D True‐FISP sequence for morphologic assessment and multi‐echo spin‐echo T2‐mapping for biochemical assessment of healthy cartilage and MACT cartilage). Mean T2 values in repair tissue in the deep zone showed significantly shorter T2 times in females (p= 0.009, female 43.5 ± 9.8 vs. male 48.2 ± 7.7 ms). The superficial zone showed higher T2 values than the deep zone in both the groups (female 48.5 ± 9.8, males 52.6 ± 11.0 ms) without significant difference between female and male patients. Native control cartilage showed no statistically significant differences for T2 between females and males. The subdivisions “structure of the repair tissue” and “subchondral bone” of the MOCART score showed statistically significant differences between females and males (p= 0.026 andp= 0.007) as well as the Lysholm score (p= 0.03). Our investigations revealed differences between female and male patients after MACT of the knee in clinical outcome and advanced morphological and biochemical MRI. The presented imaging biomarkers can depict subtle changes after cartilage regeneration procedures and might help to understand gender related differences after cartilage repair procedures. © 2014 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 32:1341–1348, 2014.
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自体软骨细胞移植治疗膝关节软骨缺损。
DOI：
--
发表时间：
2004
期刊：
Der Radiologe
影响因子：
--
作者：
S. Marlovits;F. Kutscha;S. Aldrian;C. Resinger;P. Singer;Philip Zeller;Vilmos V csei
通讯作者：
Vilmos V csei
影响因子：
4.8
作者：
A. Anderson;J. Irrgang;M. Kocher;Barton J. Mann;J. Harrast
通讯作者：
J. Harrast
磁共振成像与膝关节软骨修复手术后临床结果的相关性
影响因子：
4.8
作者：
A. Blackman;Matthew V. Smith;D. Flanigan;M. Matava;R. Wright;R. Brophy
通讯作者：
R. Brophy
影响因子：
2.1
作者：
Faber, SC;Eckstein, F;Reiser, M
通讯作者：
Reiser, M
DOI：
10.1097/00003086-200110001-00034
发表时间：
2001-10-01
影响因子：
4.2
作者：
Chung, CB;Frank, LR;Resnick, D
通讯作者：
Resnick, D