Association between dipstick proteinuria and hearing impairment in health check-ups among Japanese workers: a cross-sectional study.
Association between dipstick proteinuria and hearing impairment in health check-ups among Japanese workers: a cross-sectional study.
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DOI：
10.1136/bmjopen-2017-021427
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发表时间：
2018-05-14
期刊：
影响因子：
2.9
通讯作者：
Kobashi G
中科院分区：
文献类型：
--
作者：
Umesawa M;Hara M;Sairenchi T;Haruyama Y;Nagao M;Matsushita M;Kobashi G
预防听力损伤是很重要的，因为它是很难恢复的。流行病学研究已经检查了听力损伤的危险因素;然而，试纸蛋白尿和听力损伤之间的关系以前没有被检查过。本研究旨在阐明试纸蛋白尿与听力损害之间的关系。横断面研究。来自日本各地的办公室和工厂工人。受试者总数为7005例。他们都是同一家公司的员工。其中，我们招募了6192名受试者，他们在每年的健康检查中接受了尿试纸测试和听力测试（平均年龄44.9岁，男性88.3%）。听力测试在日本法律规定的两个频率（1 kHz，4 kHz）下进行。我们将受试者无法对1 kHz下的30 dB和/或4 kHz下的40 dB做出反应定义为总体中度听力损伤。此外，我们将1 kHz（4 kHz）的中度听力障碍定义为1 kHz（4 kHz）的异常结果。在调整年龄、性别、体重指数、高血压、糖尿病、血清肌酐水平和噪声工作环境史后，我们研究了试纸蛋白尿程度与听力损伤之间的关系。在324例受试者（5.2%）中观察到总体中度听力损害。其中，107例受试者（1.7%）在1 kHz时有中度听力损伤，278例受试者（4.5%）在4 kHz时有中度听力损伤。试纸蛋白尿与总体中度听力损伤以及1 kHz和4 kHz的中度听力损伤显著相关。蛋白尿≥2+者中中度听力损害的患病率为23.5%，而无蛋白尿者中中度听力损害的患病率为5.2%（P<0.01）。试纸蛋白尿与日本工人中度听力损伤相关。
Prevention of hearing impairment is important because it is difficult to recover from it. Epidemiological studies have examined the risk factors for hearing impairment; however, the association between dipstick proteinuria and hearing impairment has not been previously examined. This study aimed to clarify the association between dipstick proteinuria and hearing impairment. Cross-sectional study. Office and factory workers from all over Japan. The total number of subjects was 7005. All were employees of the same company. Of these, we recruited 6192 subjects who underwent dipstick urine test and hearing test by audiometry in annual health check-ups (mean age 44.9 years, men 88.3%). Hearing tests were performed at two frequencies (1 kHz, 4 kHz) as prescribed by law in Japan. We defined the inability of subjects to respond to 30 dB at 1 kHz and/or 40 dB at 4 kHz as overall moderate hearing impairment. In addition, we defined moderate hearing impairment at 1 kHz (4 kHz) as an abnormal finding at 1 kHz (4 kHz). We examined the associations between degree of dipstick proteinuria and hearing impairment after adjustment for age, sex, body mass index, hypertension, diabetes mellitus, serum creatinine level and history of noisy work environment. Overall moderate hearing impairment was noted in 324 subjects (5.2%). Of these, 107 subjects (1.7%) had moderate hearing impairment at 1 kHz and 278 subjects (4.5%) at 4 kHz. Dipstick proteinuria was significantly associated with overall moderate hearing impairment, as well as moderate hearing impairment at both 1 kHz and 4 kHz. The prevalence of overall moderate hearing impairment among subjects with proteinuria ≥2+ was 23.5%, while that among subjects without proteinuria was 5.2% (p<0.01). Dipstick proteinuria was associated with moderate hearing impairment in Japanese workers.
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影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
4.4
作者：
Kang, Seok Hui;Jung, Da Jung;Do, Jun Young
通讯作者：
Do, Jun Young
影响因子：
5.8
作者：
Horikawa, Chika;Kodama, Satoru;Sone, Hirohito
通讯作者：
Sone, Hirohito
影响因子：
13.2
作者：
Matsuo, Seiichi;Imai, Enyu;Hishida, Akira
通讯作者：
Hishida, Akira