Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood.
Adolescent intermittent ethanol exposure diminishes anhedonia during ethanol withdrawal in adulthood.
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青少年间歇性乙醇暴露在成年期间撤离乙醇期间降低了Anhedonia。
DOI：
10.1016/j.euroneuro.2014.01.022
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发表时间：
2014-06
影响因子：
5.6
通讯作者：
Markou, Athina
中科院分区：
文献类型：
--
作者：
Boutros, Nathalie;Semenova, Svetlana;Markou, Athina
青少年饮酒可能会干扰神经发育，增加成人酒精使用障碍 (AUD) 的可能性。我们研究了青少年间歇性乙醇（AIE）暴露是否会改变成人对乙醇的奖赏反应。青春期大鼠以 2 天给药/2 天停药的模式每天给予乙醇一次（中度暴露；队列 1）或 3 次（重度暴露；队列 2）。在成年期，受试者在离散试验颅内自刺激（ICSS）程序中对针对下丘脑后外侧部的电刺激做出反应，该程序提供电流强度阈值作为大脑奖赏功能的衡量标准。评估了乙醇给药和停药的效果。对照大鼠在急性乙醇后表现出剂量依赖性阈值升高，表明奖励缺陷。大多数中度 AIE 暴露的大鼠（队列 1）在乙醇后表现出阈值降低，表明乙醇诱导该大鼠亚组的奖励增强。暴露于严重 AIE 的大鼠（队列 2）没有表现出阈值升高或降低，表明情感乙醇反应减弱。每日乙醇会在对照组大鼠给药 24 小时后诱导阈值升高，但在任何一组暴露于 AIE 的大鼠中均未出现阈值升高，这表明对乙醇戒断的负面情感状态的敏感性降低。尽管暴露于严重 AIE 的大鼠的阈值升高有所降低，但从 4 天的乙醇暴饮中戒断后，所有大鼠的阈值均出现了强烈且持久的升高。这些结果表明，AIE 暴露减少了与乙醇中毒和戒断相关的奖赏缺陷，并且可能增加了一部分大鼠中乙醇诱导的奖赏增强。在人类中，乙醇奖励的增加以及戒断严重程度的降低可能有助于 AUD 的发展。
Adolescent alcohol use may interfere with neurodevelopment, increasing the likelihood of adult alcohol use disorders (AUDs). We investigated whether adolescent intermittent ethanol (AIE) exposure alters the adult reward response to ethanol. Adolescent rats were administered ethanol once (moderate exposure; Cohort 1) or three times per day (severe exposure; Cohort 2) in a 2 days on/2 days off pattern. In adulthood, subjects responded for electrical stimulation directed at the posterior lateral hypothalamus in a discrete-trials intracranial self-stimulation (ICSS) procedure that provides current-intensity thresholds as a measure of brain reward function. The effects of ethanol administration and withdrawal were assessed. Control rats showed dose-dependent threshold elevations after acute ethanol, indicating reward deficits. A majority of moderately AIE-exposed rats (Cohort 1) showed threshold lowering after ethanol, suggesting ethanol-induced reward enhancement in this sub-set of rats. Rats exposed to severe AIE (Cohort 2) showed no threshold elevation or lowering, suggesting blunted affective ethanol response. Daily ethanol induced threshold elevations 24 h after administration in control but not in either group of AIE-exposed rats, suggesting decreased sensitivity to the negative affective state of ethanol withdrawal. Withdrawal from a 4-day ethanol binge produced robust and enduring threshold elevations in all rats, although threshold elevations were diminished in rats exposed to severe AIE. These results indicate that AIE exposure diminished reward deficits associated with ethanol intoxication and withdrawal and may have increased ethanol-induced reward enhancement in a sub-set of rats. In humans, enhanced ethanol reward accompanied by reduced withdrawal severity may contribute to the development of AUDs.
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影响因子：
3.3
作者：
Allen CD;Rivier CL;Lee SY
通讯作者：
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DOI：
10.1111/j.1530-0277.2011.01615.x
发表时间：
2012-02-01
影响因子：
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作者：
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作者：
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