Spontaneously Emerging Patterns in Human Visual Cortex Reflect Responses to Naturalistic Sensory Stimuli
Spontaneously Emerging Patterns in Human Visual Cortex Reflect Responses to Naturalistic Sensory Stimuli
复制标题
人类视觉皮层自发出现的模式反映了对自然感官刺激的反应
作者：
Meytal Wilf;Francesca Strappini;Tal Golan;Avital Hahamy;M. Harel;R. Malach
摘要在没有刺激或任务的情况下，大脑皮层自发地产生丰富而一致的功能连接模式（称为静息态网络），即使在个别皮层区域也是显而易见的。我们和其他人以前假设，日常生活中习惯性的皮层网络激活有助于这些连接模式的形成。在这里，我们通过使用血氧水平依赖性功能磁共振成像，比较在视网膜定位视觉区休息期间自发出现的连接模式与自然视觉刺激（重复电影片段）产生的模式来验证这一假设。然后将这些与由更标准的视网膜定位映射刺激（极性和偏心映射）产生的连接模式进行比较。我们的研究结果表明，与偏心或极映射刺激的连接模式相比，电影驱动的模式与自发出现的模式更相似。自然刺激的有意视觉意象不太可能成为这些结果的基础，因为当参与者参与听觉任务时，它们会被复制。我们的研究结果表明，在休息时出现的连接模式更好地反映了自然的激活，而不是控制，人工设计的刺激。结果是兼容的假设，即在人类retinotopic地区的自发连接模式反映了统计的皮质共激活在自然视觉。
Abstract In the absence of stimulus or task, the cortex spontaneously generates rich and consistent functional connectivity patterns (termed resting state networks) which are evident even within individual cortical areas. We and others have previously hypothesized that habitual cortical network activations during daily life contribute to the shaping of these connectivity patterns. Here we tested this hypothesis by comparing, using blood oxygen level‐dependent‐functional magnetic resonance imaging, the connectivity patterns that spontaneously emerge during rest in retinotopic visual areas to the patterns generated by naturalistic visual stimuli (repeated movie segments). These were then compared with connectivity patterns produced by more standard retinotopic mapping stimuli (polar and eccentricity mapping). Our results reveal that the movie‐driven patterns were significantly more similar to the spontaneously emerging patterns, compared with the connectivity patterns of either eccentricity or polar mapping stimuli. Intentional visual imagery of naturalistic stimuli was unlikely to underlie these results, since they were duplicated when participants were engaged in an auditory task. Our results suggest that the connectivity patterns that appear during rest better reflect naturalistic activations rather than controlled, artificially designed stimuli. The results are compatible with the hypothesis that the spontaneous connectivity patterns in human retinotopic areas reflect the statistics of cortical coactivations during natural vision.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
视觉皮层在盲人中的功能连通性遵循视网膜组织原理。
DOI：
10.1093/brain/awv083
发表时间：
2015-06
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Striem-Amit E;Ovadia-Caro S;Caramazza A;Margulies DS;Villringer A;Amedi A
通讯作者：
Amedi A
影响因子：
3.7
作者：
Stevens, W. Dale;Buckner, Randy L.;Schacter, Daniel L.
通讯作者：
Schacter, Daniel L.
影响因子：
56.9
作者：
SERENO, MI;DALE, AM;TOOTELL, RBH
通讯作者：
TOOTELL, RBH
DOI：
10.1073/pnas.200033797
发表时间：
2000-09-26
影响因子：
11.1
作者：
Fischl, B;Dale, AM
通讯作者：
Dale, AM