Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel.
Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel.
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DOI：
10.1177/1352458511408991
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发表时间：
2011-10
期刊：
影响因子：
--
通讯作者：
Ascherio A
中科院分区：
文献类型：
--
作者：
Munger KL;Levin LI;O'Reilly EJ;Falk KI;Ascherio A
EB病毒（EBV）抗体滴度升高是MS的危险因素，但这种关联的强度和一致性尚未得到很好的表征。为了确定这种关联是否被维生素D混淆或被性别或种族修饰，以及EBV核抗原（EBNA）抗体作为MS标志物的有用性，我们在美国军事人员中进行了一项前瞻性研究。对EBV抗原的抗体滴度进行了测量，血清样本从222个人谁开发MS和444年龄，性别和种族/民族匹配的控制。条件Logistic回归用于估计相对危险度。MS风险随着抗EBNA复合物（p<10−9）和抗EBNA-1（p=5.8E-9）滴度的增加而增加。抗EBNA复合物IgG滴度≥320的个体MS风险比滴度<20的个体高36倍（95%CI：9.6-136），抗EBNA-1抗体滴度≥320的个体MS风险比抗EBNA-1抗体滴度<20的个体MS风险高8倍（95%CI：2.6-23）。这些关联在性别和种族/民族群体中是一致的，并且独立于25-羟基维生素D水平。EBNA复合物的ROC曲线下面积为0.67，EBNA-1的ROC曲线下面积为0.65。发病前抗EBNA抗体的血清滴度是MS风险的强有力的标志物，并且可以用于MS风险评分。
Elevated Epstein-Barr virus (EBV) antibody titers are risk factors for MS, but the strength and consistency this association are not well characterized. To determine whether this association is confounded by vitamin D or modified by gender or race, and the usefulness of EBV nuclear antigen (EBNA) antibodies as a marker for MS. We conducted a prospective study among US military personnel. Antibody titers against EBV antigens were measured in serum samples from 222 individuals who developed MS and 444 age, sex, and race/ethnicity matched controls. Conditional logistic regression was used to estimate relative risks. MS risk increased with increasing titers of anti-EBNA complex (p<10−9) and anti-EBNA-1 (p=5.8E-9) titers. MS risk was 36-fold higher among individuals with anti-EBNA complex IgG titers ≥320 than among those with titers <20 (95%CI:9.6-136), and 8-fold higher among those with anti-EBNA-1 ≥320 than among those with anti-EBNA-1 <20 (95%CI:2.6-23). These associations were consistent across gender and race/ethnicity groups and independent from 25-hydroxyvitamin D levels. Areas under the ROC curves were 0.67 for EBNA complex and 0.65 for EBNA-1. Serum titers of pre-onset anti-EBNA antibodies are strong, robust markers of MS risk and could be useful in an MS risk score.
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