Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.
Enhanced Healthspan in Caenorhabditis elegans Treated With Extracts From the Traditional Chinese Medicine Plants Cuscuta chinensis Lam. and Eucommia ulmoides Oliv.
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DOI：
10.3389/fphar.2021.604435
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发表时间：
2021
影响因子：
5.6
通讯作者：
Saul N
中科院分区：
文献类型：
--
作者：
Sayed SMA;Siems K;Schmitz-Linneweber C;Luyten W;Saul N
为了揭示中药的潜在抗衰老作用，以线虫线虫为研究对象，通过筛选筛选出7种中药提取物，研究了杜仲叶提取物和决明子提取物对人体不同健康寿命参数的影响。从幼虫阶段开始，暴露于紫锥菊和中华绒毛虫提取物的线虫在热应激和暴露于致病细菌发光菌后表现出更长的寿命和更高的存活率，从而监测在不同成虫阶段开始应激后的生存效益。然而，只有中华绒毛虫具有增强体能的能力：线虫的游泳行为和咽泵率在第7天有所改善，尤其是在成虫第12天。最后，监测老化蠕虫的红色荧光发现，只有中华绒毛虫提取物能抑制肠道自发荧光，这是一种已知的衰老标志。这些结果突显了受试植物提取物的不同作用模式。紫球藻通过提高线虫在胁迫后的存活概率来提高其生理适合度，而中国线虫似乎是一种全面的健康增强剂，反映在抑制的自体荧光上，对身体和生理适合度都有好处。中华绒毛虫的作用可能是节律的：这是由HSP-16.1基因表达的增加和HSP-12.6的趋势所支持的。
To uncover potential anti-aging capacities of Traditional Chinese Medicine (TCM), the nematode Caenorhabditis elegans was used to investigate the effects of Eucommia ulmoides and Cuscuta chinensis extracts, selected by screening seven TCM extracts, on different healthspan parameters. Nematodes exposed to E. ulmoides and C. chinensis extracts, starting at the young adult stage, exhibited prolonged lifespan and increased survival after heat stress as well as upon exposure to the pathogenic bacterium Photorhabdus luminescens, whereby the survival benefits were monitored after stress initiation at different adult stages. However, only C. chinensis had the ability to enhance physical fitness: the swimming behavior and the pharyngeal pumping rate of C. elegans were improved at day 7 and especially at day 12 of adulthood. Finally, monitoring the red fluorescence of aged worms revealed that only C. chinensis extracts caused suppression of intestinal autofluorescence, a known marker of aging. The results underline the different modes of action of the tested plants extracts. E. ulmoides improved specifically the physiological fitness by increasing the survival probability of C. elegans after stress, while C. chinensis seems to be an overall healthspan enhancer, reflected in the suppressed autofluorescence, with beneficial effects on physical as well as physiological fitness. The C. chinensis effects may be hormetic: this is supported by increased gene expression of hsp-16.1 and by trend, also of hsp-12.6.
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影响因子：
64.5
作者：
de Cabo R;Carmona-Gutierrez D;Bernier M;Hall MN;Madeo F
通讯作者：
Madeo F
DOI：
10.1073/pnas.0400848101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Huang, C;Xiong, CJ;Kornfeld, K
通讯作者：
Kornfeld, K
影响因子：
--
作者：
Han SK;Lee D;Lee H;Kim D;Son HG;Yang JS;Lee SV;Kim S
通讯作者：
Kim S
影响因子：
--
作者：
Büchter C;Zhao L;Havermann S;Honnen S;Fritz G;Proksch P;Wätjen W
通讯作者：
Wätjen W
影响因子：
5.4
作者：
Dharmalingam, Komalavali;Tan, Boon-Khai;Shu-Chien, Alexander Chong
通讯作者：
Shu-Chien, Alexander Chong