Alcohol and the risk of Barrett's esophagus: a pooled analysis from the International BEACON Consortium.
Alcohol and the risk of Barrett's esophagus: a pooled analysis from the International BEACON Consortium.
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酒精和巴雷特食管的风险：来自国际标准联盟的合并分析。
DOI：
10.1038/ajg.2014.206
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发表时间：
2014-10
影响因子：
9.8
通讯作者：
Corley, Douglas A.
中科院分区：
文献类型：
--
作者：
Thrift, Aaron P.;Cook, Michael B.;Vaughan, Thomas L.;Anderson, Lesley A.;Murray, Liam J.;Whiteman, David C.;Shaheen, Nicholas J.;Corley, Douglas A.
关于饮酒与巴雷特食道风险之间关系的研究结果并不一致。我们通过汇集参加国际Barrett‘s和食管腺癌联盟(Beacon)的五项病例对照研究的个人参与者数据，评估了Barrett’s食道与总饮酒量和特定饮酒有关的风险。为了进行分析，共有1282名人群对照、1418名胃食道反流病(GERD)对照和1169名Barrett‘s食管病患者(病例)。我们使用调整了年龄、性别、体重指数(BMI)、教育程度、吸烟状况和GERD症状的多变量Logistic回归模型，估计了研究特定优势比(OR)和95%可信区间(95%CI)。通过随机效应模型获得总体风险估计值。我们还检查了性别、BMI、GERD症状和吸烟对潜在影响的影响。与以人群为基础的对照组相比，尽管任何饮酒与Barrett‘s食道风险之间存在边缘显著的负相关(有或无，汇总OR=0.77，95%CI为0.60-1.00)，但风险并没有以剂量-反应的方式减少(P趋势=0.72)。在酒精类型中，葡萄酒与Barrett‘s食道的风险适度降低(有或无，OR=0.71，95%CI为0.52~0.98)；然而，没有一致的剂量-反应关系(P趋势=0.21)。当病例与GERD对照组进行比较时，我们发现与饮酒无关。在BMI、GERD症状和吸烟的所有层面上都观察到了类似的关联。与食管腺癌的研究结果一致，我们没有发现任何证据表明饮酒会增加Barrett‘s食道的风险。
Results from studies examining the association between alcohol consumption and the risk of Barrett’s esophagus have been inconsistent. We assessed the risk of Barrett’s esophagus associated with total and beverage-specific alcohol consumption by pooling individual participant data from five case-control studies participating in the international Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON). For analysis there were 1282 population-based controls, 1418 controls with gastroesophageal reflux disease (GERD) and 1169 patients with Barrett’s esophagus (cases). We estimated study-specific odds ratios (OR) and 95% confidence intervals (95% CI) using multivariable logistic regression models adjusted for age, sex, body mass index (BMI), education, smoking status, and GERD symptoms. Summary risk estimates were obtained by random effects models. We also examined potential effect modification by sex, BMI, GERD symptoms and cigarette smoking. For comparisons with population-based controls, while there was a borderline statistically significant inverse association between any alcohol consumption and the risk of Barrett’s esophagus (any vs. none, summary OR=0.77, 95% CI 0.60–1.00), risk did not decrease in a dose-response manner (ptrend=0.72). Among alcohol types, wine was associated with a moderately reduced risk of Barrett’s esophagus (any vs. none, OR=0.71, 95% CI 0.52–0.98); however, there was no consistent dose-response relationship (ptrend=0.21). We found no association with alcohol consumption when cases were compared with GERD controls. Similar associations were observed across all strata of BMI, GERD symptoms and cigarette smoking. Consistent with findings for esophageal adenocarcinoma, we found no evidence that alcohol consumption increases the risk of Barrett’s esophagus.
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影响因子：
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作者：
Vasdev, Sudesh;Gill, Vicki;Singal, Pawan K
通讯作者：
Singal, Pawan K
影响因子：
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作者：
Cook, Michael B.;Shaheen, Nicholas J.;Corley, Douglas A.
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Corley, Douglas A.
影响因子：
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作者：
Thrift, A. P.;Whiteman, D. C.
通讯作者：
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影响因子：
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作者：
Kubo A;Cook MB;Shaheen NJ;Vaughan TL;Whiteman DC;Murray L;Corley DA
通讯作者：
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DOI：
10.1158/1940-6207.capr-12-0010
发表时间：
2012-09
期刊：
Cancer prevention research (Philadelphia, Pa.)
影响因子：
--
作者：
Thrift AP;Kendall BJ;Pandeya N;Vaughan TL;Whiteman DC;Study of Digestive Health
通讯作者：
Study of Digestive Health