Diabetes risk assessment in Mexicans and Mexican Americans: effects of parental history of diabetes are modified by adiposity level.
Diabetes risk assessment in Mexicans and Mexican Americans: effects of parental history of diabetes are modified by adiposity level.
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DOI：
10.2337/dc10-0992
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发表时间：
2010-10
期刊：
影响因子：
16.2
通讯作者：
Hsueh WC
中科院分区：
文献类型：
--
作者：
Velasco Mondragon HE;Charlton RW;Peart T;Burguete-Garcia AI;Hernandez-Avila M;Hsueh WC
Parental diabetes history is a well-known risk factor for type 2 diabetes and considered strong evidence for a genetic basis of type 2 diabetes. Whether this relationship is affected by other known risk factors, specifically obesity, remains unclear, possibly due to a relative paucity of lean diabetic patients. This issue was investigated using data from a high-risk population from Mexico (National Health Survey 2000, n = 27,349), with observations replicated using U.S. citizens of Mexican descent from the National Health and Nutrition Examination Survey 2001–2002 and 2003–2004 (n = 1,568). As expected, positive parental diabetes was a significant risk factor for type 2 diabetes, regardless of age, sex, or adiposity level. However, positive parental diabetes conferred greater risk in leaner individuals than in their overweight peers (P = 0.001). In other words, the effect of BMI on type 2 diabetes risk was smaller in the presence of parental diabetes history. These findings suggest that parental diabetes is a stronger risk factor for type 2 diabetes in the absence of obesity. Thus, studies in lean diabetic patients could help identify type 2 diabetes susceptibility genes. This study reinforces the concept that parental diabetes and BMI are independent type 2 diabetes risk factors and suggests that glycemic screening may be helpful in assessing type 2 diabetes risk in individuals with parental diabetes history, regardless of their overweight status.
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影响因子：
5.1
作者：
Puavilai, G;Chanprasertyotin, S;Sriphrapradaeng, A
通讯作者：
Sriphrapradaeng, A
影响因子：
5.8
作者：
Molyneaux, L;Constantino, M;Yue, D
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Yue, D
影响因子：
5.5
作者：
Harrison, TA;Hindorff, LA;Edwards, KL
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Edwards, KL
影响因子：
56.9
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Frayling, Timothy M.;Timpson, Nicholas J.;McCarthy, Mark I.
通讯作者：
McCarthy, Mark I.
影响因子：
5
作者：
MORRIS, RD;RIMM, DL;RIMM, AA
通讯作者：
RIMM, AA