Abnormal resting-state activities and functional connectivities of the anterior and the posterior cortexes in medication-naïve patients with obsessive-compulsive disorder.
Abnormal resting-state activities and functional connectivities of the anterior and the posterior cortexes in medication-naïve patients with obsessive-compulsive disorder.
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DOI：
10.1371/journal.pone.0067478
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Cheng Y;Xu J;Nie B;Luo C;Yang T;Li H;Lu J;Xu L;Shan B;Xu X
强迫症（OCD）是一种以失控为特征的精神疾病。由于扣带皮层被认为在执行功能（如抑制）中起重要作用，我们使用功能性磁共振成像（fMRI）技术来检查未用药的强迫症患者扣带皮层的活动和功能连接（FC）是否以及如何发生改变。
23名未用药的强迫症患者和23名匹配良好的健康对照在静息状态下接受了fMRI扫描。基于低频波动振幅分数（fALFF）确定的感兴趣区域（ROI），通过相关性分析来分析前扣带（ACC）和后扣带（PCC）与全脑的功能连接。使用独立成分分析（ICA）来识别静息状态子网络。
fALFF分析发现，与对照组相比，强迫症患者ACC区域的活动增加，PCC区域的活动减少。ACC和PCC的功能连接也呈现出不同的模式。在ICA分析中发现ACC和PCC属于不同的静息状态子网络，并且显示出异常的功能连接，以及与强迫症症状严重程度的对比相关性。
与对照组相比，未用药的强迫症患者ACC的活动增加，PCC的活动减少。在这两组之间，ACC和PCC的功能连接也发现了不同的模式。这些发现暗示强迫症的主要特征——失控，可能归因于ACC和PCC的异常活动和功能连接。
Obsessive-compulsive disorder (OCD) is a mental illness characterized by the loss of control. Because the cingulate cortex is believed to be important in executive functions, such as inhibition, we used functional magnetic resonance imaging (fMRI) techniques to examine whether and how activity and functional connectivity (FC) of the cingulate cortex were altered in drug-naïve OCD patients. Twenty-three medication-naïve OCD patients and 23 well-matched healthy controls received fMRI scans in a resting state. Functional connectivities of the anterior cingulate (ACC) and the posterior cingulate (PCC) to the whole brain were analyzed using correlation analyses based on regions of interest (ROI) identified by the fractional amplitude of low-frequency fluctuation (fALFF). Independent Component Analysis (ICA) was used to identify the resting-state sub-networks. fALFF analysis found that regional activity was increased in the ACC and decreased in the PCC in OCD patients when compared to controls. FC of the ACC and the PCC also showed different patterns. The ACC and the PCC were found to belong to different resting-state sub-networks in ICA analysis and showed abnormal FC, as well as contrasting correlations with the severity of OCD symptoms. Activity of the ACC and the PCC were increased and decreased, respectively, in the medication-naïve OCD patients compared to controls. Different patterns in FC were also found between the ACC and the PCC with respect to these two groups. These findings implied that the cardinal feature of OCD, the loss of control, may be attributed to abnormal activities and FC of the ACC and the PCC.
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