Evidence of Non-Linear Associations between Frustration-Related Prefrontal Cortex Activation and the Normal:Abnormal Spectrum of Irritability in Young Children.
Evidence of Non-Linear Associations between Frustration-Related Prefrontal Cortex Activation and the Normal:Abnormal Spectrum of Irritability in Young Children.
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DOI：
10.1007/s10802-017-0286-5
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发表时间：
2018-01
影响因子：
3.6
通讯作者：
Perlman SB
中科院分区：
文献类型：
--
作者：
Grabell AS;Li Y;Barker JW;Wakschlag LS;Huppert TJ;Perlman SB
对儿童早期易激惹的兴趣最近转向神经影像学技术，以更好地了解正常与异常的易激惹使用维度的方法。经常账户在很大程度上假设了挫折管理不善、易怒的表现及其潜在的神经回路之间的线性关系。然而，这些构建体之间的关系可能不是线性的（即，在整个易怒谱的不同点上有不同的作用），这对如何识别和治疗早期非典型易怒有影响。我们的目标是通过测试非线性关联来研究挫折相关的外侧前额叶皮层（LPFC）激活和易怒之间的关联如何在易怒的维度谱中有所不同。儿童（N = 92;年龄3-7岁）完成挫折诱导任务，同时我们使用fNIRS记录LPFC血红蛋白水平。孩子们在任务中自我评估他们的情绪，父母评估他们孩子的易怒程度。而线性模型显示，挫折相关的LPFC激活和易怒之间没有关系，二次模型显示，挫折相关的LPFC激活增加，家长报告的易怒分数增加的正常范围内的易怒，但减少与增加易怒的严重范围内，在第91百分位的顶点。作为补充，我们发现，儿童的自我情绪评级在挫折与并发LPFC激活作为一个倒U函数，这样的孩子谁报告轻度困扰有更大的激活比同龄人报告没有或高的困扰。结果表明，儿童与相对较高的易怒谁是未受损的可能拥有发达的LPFC的支持，一种机制，退出在严重的一端的易怒的尺寸。研究结果提出了新的途径，了解早期易怒的异质性及其临床后遗症。
Burgeoning interest in early childhood irritability has recently turned toward neuroimaging techniques to better understand normal versus abnormal irritability using dimensional methods. Current accounts largely assume a linear relationship between poor frustration management, an expression of irritability, and its underlying neural circuitry. However, the relationship between these constructs may not be linear (i.e., operate differently at varying points across the irritability spectrum), with implications for how early atypical irritability is identified and treated. Our goal was to examine how the association between frustration-related lateral prefrontal cortex (LPFC) activation and irritability differs across the dimensional spectrum of irritability by testing for non-linear associations. Children (N = 92; ages 3–7) ranging from virtually no irritability to the upper end of the clinical range completed a frustration induction task while we recorded LPFC hemoglobin levels using fNIRS. Children self-rated their emotions during the task and parents rated their child’s level of irritability. Whereas a linear model showed no relationship between frustration-related LPFC activation and irritability, a quadratic model revealed frustration-related LPFC activation increased as parent-reported irritability scores increased within the normative range of irritability but decreased with increasing irritability in the severe range, with an apex at the 91st percentile. Complementarily, we found children’s self-ratings of emotion during frustration related to concurrent LPFC activation as an inverted U function, such that children who reported mild distress had greater activation than peers reporting no or high distress. Results suggest children with relatively higher irritability who are unimpaired may possess well-developed LPFC support, a mechanism that drops out in the severe end of the irritability dimension. Findings suggest novel avenues for understanding the heterogeneity of early irritability and its clinical sequelae.
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影响因子：
1.9
作者：
Blair, Robert J. R.
通讯作者：
Blair, Robert J. R.
影响因子：
4
作者：
COLE, PM;ZAHNWAXLER, C;SMITH, KD
通讯作者：
SMITH, KD
DOI：
10.1016/j.jaac.2013.09.007
发表时间：
2013-12-01
影响因子：
13.3
作者：
Dougherty, Lea R.;Smith, Victoria C.;Klein, Daniel N.
通讯作者：
Klein, Daniel N.
影响因子：
12.8
作者：
Grave, J;Blissett, J
通讯作者：
Blissett, J
影响因子：
22.4
作者：
BERKOWITZ, L
通讯作者：
BERKOWITZ, L