Principles and concepts of DNA replication in bacteria, archaea, and eukarya.

Principles and concepts of DNA replication in bacteria, archaea, and eukarya.
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DOI:
10.1101/cshperspect.a010108
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发表时间:
2013-07-01
影响因子:
7.2
通讯作者:
Stillman B
Stillman B
中科院分区:
生物学1区
文献类型:
--
作者:
O'Donnell M;Langston L;Stillman B

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DNA双螺旋结构中遗传信息的准确复制对于决定细胞和生物体表型的性状的遗传至关重要。复制DNA的核心机制在细菌、古生菌和真核生物这三个生命领域中都是保守的。这一介绍性章节概述了DNA复制机制的一般性质,但也指出了重要和关键的区别。最复杂的生物,真核生物,必须协调每个基因组中来自许多起源的DNA复制的起始,并施加调节以保持基因组的完整性,这不仅是为了每个细胞,也是为了整个生物体。此外,真核生物的DNA复制需要与染色质遗传、组织发育模式和细胞分裂协调,以确保每个细胞分裂周期基因组复制一次。
The accurate copying of genetic information in the double helix of DNA is essential for inheritance of traits that define the phenotype of cells and the organism. The core machineries that copy DNA are conserved in all three domains of life, bacteria, archaea and eukaryotes. This introductory chapter outlines the general nature of the DNA replication machinery, but also points out important and key differences. The most complex organisms, eukaryotes, have to coordinate the initiation of DNA replication from many origins in each genome and impose regulation that maintains genomic integrity, not only for the sake of each cell, but for the organism as a whole. In addition, DNA replication in eukaryotes needs to be coordinated with inheritance of chromatin, developmental patterning of tissues and with cell division to ensure that the genome replicates once per cell division cycle.
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