Electroacupuncture as a rapid-onset and safer complementary therapy for depression: A systematic review and meta-analysis.
Electroacupuncture as a rapid-onset and safer complementary therapy for depression: A systematic review and meta-analysis.
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电针作为一种快速起效且更安全的抑郁症补充疗法：系统评价和荟萃分析
DOI：
10.3389/fpsyt.2022.1012606
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发表时间：
2022
影响因子：
4.7
通讯作者：
Huang, Yong
中科院分区：
文献类型：
--
作者：
Zhang, Zhinan;Cai, Xiaowen;Liang, Yuying;Zhang, Rui;Liu, Xinyu;Lu, Liming;Huang, Yong
电针（EA）是一种很有前途的治疗抑郁症的方法。然而，需要对EA治疗抑郁症进行全面的审查。我们根据系统评价和荟萃分析的首选报告项目（PRISMA 2020）指南进行了系统评价和荟萃分析，以评估EA治疗抑郁症的有效性和安全性。从成立到2022年3月，在MEDLINE、EMBASE、PsycINFO和CENTRAL中检索了可能相关的试验和综述。EA单独和联合其他治疗均符合纳入条件。治疗期间和治疗后抑郁症的严重程度以及不良事件的数量被评估为结果。进行偏倚风险（ROB）评价、亚组分析、敏感性分析、报告偏倚评价和GRADE系统评价。纳入34项试验。总体罗伯为中等。低质量证据显示，EA的疗效不低于抗抑郁药[EA +选择性5 -羟色胺再摄取抑制剂（SSRIs）和三环抗抑郁药（TCAs）]和手针刺（MA）。EA和EA + SSRIs在早期治疗中降低抑郁严重程度的效果优于单独使用SSRIs。中等质量的证据也表明，EA和EA + SSRIs比单独使用SSRIs更安全。敏感性分析大多不可行。不太可能存在重大发表偏倚。这些结果表明，EA的疗效不低于抗抑郁药和MA。此外，EA和EA + SSRI治疗比SSRIs起效更快，安全性更高。需要更多高质量的试验来进一步证实。[www.crd.york.ac.uk /普洛斯彼罗/ display_ record.php吗?RecordID=329143]，标识符[CRD42022329143]。
Electroacupuncture (EA) is a promising therapy for depression. However, a comprehensive review of EA for depression is needed. We conducted a systematic review and meta-analysis in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA 2020) guidelines to evaluate the efficacy and safety of EA for depression. Potentially relevant trials and reviews were searched in MEDLINE, EMBASE, PsycINFO, and CENTRAL from inception to March 2022. EA alone and combined with other therapy were eligible for inclusion. The severity of depression during and after treatment and the number of adverse events were assessed as outcomes. Risk of bias (ROB) evaluation, subgroup analysis, sensitivity analysis, reporting bias assessment, and GRADE system evaluation were also conducted. Thirty-four trials were included. The overall ROB was medium. Low-quality evidence showed that the efficacy of EA was not less than that of antidepressants [EA + selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs)] and manual acupuncture (MA). EA and EA + SSRIs had better efficacy than SSRIs alone in decreasing the severity of depression during the early treatment. Moderate-quality evidence also showed that EA and EA + SSRIs were safer than SSRIs alone. Sensitivity analysis was mostly not feasible. Major publication bias was unlikely. These results indicate that the efficacy of EA is not less than that of antidepressants and MA. Moreover, EA and EA + SSRI treatments show a more rapid onset and greater safety than SSRIs. More high-quality trials are needed for further confirmation. [www.crd.york.ac.uk/prospero/display_ record.php?RecordID=329143], identifier [CRD42022329143].
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