Programmed DNA Elimination in Vertebrates.

Programmed DNA Elimination in Vertebrates.
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脊椎动物中的程序化DNA消除。

DOI:
10.1146/annurev-animal-061220-023220
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发表时间:
2021-02-16
影响因子:
12
通讯作者:
Saraceno C
Saraceno C
中科院分区:
农林科学1区
文献类型:
--
作者:
Smith JJ;Timoshevskiy VA;Saraceno C

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在过去的几十年里,越来越多的脊椎动物类群已被确定在发育过程中经历程序性基因组重排或程序性DNA丢失。在这些生物体中,生殖细胞的基因组通常与体内所有其他细胞的基因组可重复地不同。尽管我们显然还没有确定所有经历基因组程序性丢失的脊椎动物分类群,但已知经历基因组丢失的物种清单现在代表了约10%的脊椎动物物种,包括几个基本分歧的谱系。最近的研究为DNA丢失的靶点和机制以及它们与DNA沉默的典型模式的关联提供了新的线索。最终,将这些研究扩展到更大的分类群中,将有助于重建脊椎动物谱系中程序性DNA丢失的共享/独立祖先模式,以及最近的进化事件,这些事件塑造了被消除的DNA的结构和内容。
Over the last few decades, an increasing number of vertebrate taxa have been identified that undergo programmed genome rearrangement, or programmed DNA loss, during development. In these organisms, the genome of germ cells is often reproducibly different from the genome of all other cells within the body. Although we clearly have not identified all vertebrate taxa that undergo programmed genome loss, the list of species known to undergo loss now represents ~10% of vertebrate species, including several basally diverging lineages. Recent studies have shed new light on the targets and mechanisms of DNA loss and their association with canonical modes of DNA silencing. Ultimately, expansion of these studies into a larger collection of taxa will aid in reconstructing patterns of shared/independent ancestry of programmed DNA loss in the vertebrate lineage, as well as more recent evolutionary events that have shaped the structure and content of eliminated DNA.
DOI: 10.1083/jcb.153.4.865
发表时间: 2001-05-14
期刊: The Journal of cell biology
影响因子: --
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