B Lymphocytes in Rheumatoid Arthritis and the Effects of Anti-TNF-α Agents on B Lymphocytes: A Review of the Literature.
B Lymphocytes in Rheumatoid Arthritis and the Effects of Anti-TNF-α Agents on B Lymphocytes: A Review of the Literature.
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DOI：
10.1016/j.clinthera.2018.04.016
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发表时间：
2018-06
影响因子：
3.2
通讯作者：
Frasca D
中科院分区：
文献类型：
--
作者：
Pala O;Diaz A;Blomberg BB;Frasca D
综述已发表的与类风湿性关节炎中B淋巴细胞相关的研究，它们在疾病发病机制中的作用，以及用TNF-α抑制剂阻断TNF-α对B淋巴细胞、感染风险和疫苗应答的影响。通过PubMed检索，对风湿性关节炎中B淋巴细胞和抗TNF-α对B淋巴细胞影响的最新研究进展进行综述。B淋巴细胞在风湿性关节炎的发病机制中起重要作用。在这篇综述中，我们总结了B淋巴细胞在疾病的发展和传播中发挥病理作用的主要机制，因为B淋巴细胞被募集到滑液中，它们通过分泌促炎介质（细胞因子，趋化因子，micro-RNA）并将抗原呈递给T细胞来促进局部炎症。我们讨论了TNF-α对表达该细胞因子受体的B淋巴细胞的直接或间接影响。我们还发现，与健康对照组相比，风湿性关节炎患者血液中的总B细胞数量减少，但在接受抗TNF-α治疗的患者中显著增加至正常水平。至于B细胞亚群，有争议的结果已经报道，研究显示总记忆B细胞（和记忆亚群）的频率降低，其他研究显示患者与健康对照组没有差异。研究抗TNF-α治疗的影响的研究也给出了有争议的结果，发现与健康对照组相比，抗TNF-α治疗可增加或不增加风湿性关节炎患者记忆B淋巴细胞的频率。这些高度可变的结果可能是由于患者特征的差异和受试者数量有限，这表明显然需要更大和更全面的研究。最后，我们总结了用抗TNF-α药物阻断TNF-α对风湿性关节炎患者可能感染的影响以及对疫苗接种的反应。
To review published research related to B lymphocytes in Rheumatoid arthritis, their role in the pathogenesis of the disease and the effects of blocking TNF-α with TNF-α inhibitors on B lymphocytes, risk of infection and responses to vaccines. PubMed search was conducted to review recent advances related to B lymphocytes and effects of anti-TNF-α on B lymphocytes in Rheumatoid Arthritis. B lymphocytes play an important role in the pathogenesis of Rheumatoid Arthritis. In this review, we summarize major mechanisms by which B lymphocytes play a pathologic role in the development and propagation of the disease, as B lymphocytes are recruited to the synovial fluid where they contribute to local inflammation through the secretion of pro-inflammatory mediators (cytokines, chemokines, micro-RNAs) and present antigens to T cells. We discuss the effects of TNF-α, either direct or indirect, on B lymphocytes expressing receptors for this cytokine. We also show that total B cell numbers have been reported to be reduced in the blood of Rheumatoid arthritis patients versus healthy controls, but significantly increased up to normal levels in patients undergoing anti-TNF-α therapy. As for B cell subsets, controversial results have been reported with studies showing decreased frequencies of total memory B cells (and memory subsets) and other showing no differences in patients versus healthy controls. Studies investigating the effects of anti-TNF-α therapy also gave controversial results, with therapy found to increase or not the frequency of memory B lymphocytes, in patients with Rheumatoid arthritis versus healthy controls. Those highly variable results could be due to differences in patient characteristics and limited number of subjects, suggesting that there is a clear need for larger and more comprehensive studies. Finally, we summarize the effects of blocking TNF-α with anti-TNF-α agents on possible infections that Rheumatoid arthritis patients may contract as well as on responses to vaccination.
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影响因子：
8.6
作者：
Banko, Zsuzsanna;Pozsgay, Judit;Sarmay, Gabriella
通讯作者：
Sarmay, Gabriella
影响因子：
7.3
作者：
Alivernini S;Gremese E;McSharry C;Tolusso B;Ferraccioli G;McInnes IB;Kurowska-Stolarska M
通讯作者：
Kurowska-Stolarska M
影响因子：
158.5
作者：
COBB, S;ANDERSON, F;BAUER, W
通讯作者：
BAUER, W
影响因子：
4.6
作者：
Conigliaro, P.;Triggianese, P.;Perricone, R.
通讯作者：
Perricone, R.
影响因子：
15.9
作者：
ALSPAUGH, MA;HENLE, G;HENLE, W
通讯作者：
HENLE, W