Relationship between anti-Tax antibody responses and cocultivatable virus in HTLV-I-infected rabbits.
Relationship between anti-Tax antibody responses and cocultivatable virus in HTLV-I-infected rabbits.
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HTLV-I 感染兔中抗 Tax 抗体反应与可共培养病毒之间的关系。
DOI：
10.1006/viro.1998.9378
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Marriott,SJ
中科院分区：
文献类型：
--
作者：
Lydy,SL;Conner,ME;Marriott,SJ
The presence of anti-Tax antibody responses in human T cell leukemia virus type I (HTLV-I)-infected individuals has been correlated with increased proviral load, increased risk of transmitting infection, and increased risk of developing tropical spastic paraparesis/HTLV-I-associated myelopathy (TSP/HAM). In this study, a rabbit model of HTLV-I infection was used to determine whether anti-Tax antibody responses could predict the presence of virus with the potential to replicate. Seven of 14 HTLV-I-infected rabbits developed anti-Tax antibody responses. The onset of Tax reactivity was variable, but once detected remained constant throughout the remainder of the 60-week course of the study. All anti-Tax antibody positive rabbits produced virus as measured by p19 expression upon coculture, while p19 was detected in only one of the Tax antibody negative animals. Thus the presence of an anti-Tax antibody response correlates with p19 expression following cocultivation, and may be a useful predictor of virus replication in HTLV-I infected individuals.
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