Maternal personality traits moderate treatment response in the Multimodal Treatment Study of attention-deficit/hyperactivity disorder.

Maternal personality traits moderate treatment response in the Multimodal Treatment Study of attention-deficit/hyperactivity disorder.
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DOI:
10.1007/s00787-019-01460-z
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发表时间:
2020-11
影响因子:
6.4
通讯作者:
Owens EB
Owens EB
中科院分区:
医学2区
文献类型:
--
作者:
Perez Algorta G;MacPherson HA;Arnold LE;Hinshaw SP;Hechtman L;Sibley MH;Owens EB

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一些患有注意力缺陷/多动障碍(ADHD)儿童的母亲表现出适应不良的人格特征(高神经质,低责任心)。母亲人格特质对儿童多动症治疗结果的调节作用尚未得到检验。我们评估母亲神经质和尽责性是否在ADHD儿童多模式治疗研究中调节反应。这是最早的此类研究之一。在一项随机对照试验(RCT)中,579名7-10岁儿童(M = 8.5);19.7%的女性;60.8%合并型ADHD的白人被随机分配到单独系统药物治疗(MedMgt)、综合多组分行为治疗(Beh)、它们的联合治疗(Comb)或社区常规比较治疗(CC)。潜在类别分析和线性混合效应模型纳入437名儿童,其生母在基线时完成了NEO五因素量表。最适合NEO的3类解决方案:MN&MC =中度神经质和尽责性(n = 284);HN&LC =高神经质,低责任心(n = 83);LN&HC =低神经质,高责任心(n = 70)。根据父母报告的症状,HN&LC而非LN&HC母亲的孩子对Beh的反应明显优于CC;母亲有MN&MC和LN&HC,而不是HN&LC的孩子对Comb&MedMgt的反应比Beh&CC好。根据教师报告的症状,患有HN&LC而非LN&HC母亲的孩子对Comb的反应明显好于MedMgt。高神经质和低责任心母亲的孩子比其他孩子从行为治疗中获益更多(Beh vs. CC; Comb vs. MedMgt)。母亲人格的评估可能有助于ADHD儿童的治疗选择,尽管这方面还需要进一步的研究。
Some mothers of children with attention-deficit/hyperactivity disorder (ADHD) present with maladaptive personality profiles (high neuroticism, low conscientiousness). The moderating effect of maternal personality traits on treatment outcomes for childhood ADHD has not been examined. We evaluate whether maternal neuroticism and conscientiousness moderated response in the Multimodal Treatment Study of Children with ADHD. This is one of the first studies of this type. In a randomized controlled trial (RCT), 579 children aged 7–10 (M = 8.5); 19.7% female; 60.8% White with combined-type ADHD were randomly assigned to systematic medication management (MedMgt) alone, comprehensive multicomponent behavioral treatment (Beh), their combination (Comb), or community comparison treatment-as-usual (CC). Latent class analysis and linear mixed effects models included 437 children whose biological mothers completed the NEO Five-Factor Inventory at baseline. A 3-class solution demonstrated best fit for the NEO: MN&MC = moderate neuroticism and conscientiousness (n = 284); HN&LC = high neuroticism, low conscientiousness (n = 83); LN&HC = low neuroticism, high conscientiousness (n = 70). Per parent-reported symptoms, children of mothers with HN&LC, but not LN&HC, had a significantly better response to Beh than to CC; children of mothers with MN&MC and LN&HC, but not HN&LC, responded better to Comb&MedMgt than to Beh&CC. Per teacher-reported symptoms, children of mothers with HN&LC, but not LN&HC, responded significantly better to Comb than to MedMgt. Children of mothers with high neuroticism and low conscientiousness benefited more from behavioral treatments (Beh vs. CC; Comb vs. MedMgt) than other children. Evaluation of maternal personality may aid in treatment selection for children with ADHD, though additional research on this topic is needed.
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