Lung function and cognitive ability in children: a UK birth cohort study.
Lung function and cognitive ability in children: a UK birth cohort study.
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儿童的肺功能和认知能力：英国出生队列研究。
DOI：
10.1136/bmjresp-2022-001528
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发表时间：
2023-05
影响因子：
4.1
通讯作者：
中科院分区：
文献类型：
--
作者：
成人肺功能下降与随后的认知障碍有关。早期生活中的类似关系可能具有重要的政策重要性，因为童年认知能力决定了成年后的关键结果，包括社会经济地位和死亡率。我们的目的是扩展儿童中这种关系的非常有限的数据，并假设肺功能降低与认知能力下降纵向相关。在Avon父母和儿童纵向研究中，在8岁时测量肺功能（第一秒用力呼气量（FEV 1），用力肺活量（FVC）; %预测值），并在8岁时测量认知能力（韦氏儿童智力量表，第三版）和15岁时测量认知能力（韦氏简明智力量表）。潜在的混杂因素包括早产、出生体重、母乳喂养时间、产前母亲吸烟、儿童环境烟草烟雾暴露、社会经济状况和产前/儿童空气污染暴露。拟合单变量和多变量线性模型（n范围=2332-6672），以评估肺功能与认知能力的横截面和纵向相关性，以及8至15岁之间认知能力的变化。在单变量分析中，8岁时的FEV 1和FVC均与两个年龄段的认知能力相关，但校正后，8岁时（β=0.09（95% CI 0.05至0.12; p<0.001））和15岁时（β=0.06（0.03至0.10; p=0.001）），仅FVC与全量表智商（FSIQ）相关。我们没有发现肺功能参数和标准化FSIQ间期变化之间存在关联的证据。FVC降低而非FEV 1与儿童认知能力下降独立相关。这种低幅度的关联在8岁到15岁之间减弱，而与认知能力的纵向变化没有明显的关联。我们的研究结果支持FVC和整个生命过程中的认知之间的联系，可能是由于共同的遗传或环境风险，而不是因果关系。
Decreased adult lung function is associated with subsequent impairment in cognition. A similar relationship in early life could be of great policy importance, since childhood cognitive ability determines key adult outcomes, including socioeconomic status and mortality. We aimed to expand the very limited data available on this relationship in children, and hypothesised that reduced lung function would be longitudinally associated with decreased cognitive ability. Lung function was measured at age 8 (forced expiratory volume in one second (FEV1), forced vital capacity (FVC); % predicted), and cognitive ability was measured at ages 8 (Wechsler Intelligence Scale for Children, third edition) and 15 (Wechsler Abbreviated Scale of Intelligence), in the Avon Longitudinal Study of Parents and Children. Potential confounders were identified as preterm birth, birth weight, breastfeeding duration, prenatal maternal smoking, childhood environmental tobacco smoke exposure, socioeconomic status and prenatal/childhood air pollution exposure. Univariable and multivariable linear models (n range=2332–6672) were fitted to assess the cross-sectional and longitudinal associations of lung function with cognitive ability, and change in cognitive ability between ages 8 and 15. In univariate analyses, both FEV1 and FVC at age 8 were associated with cognitive ability at both ages, but after adjustment, only FVC was associated with full-scale IQ (FSIQ) at ages 8 (β=0.09 (95% CI 0.05 to 0.12; p<0.001)) and 15 (β=0.06 (0.03 to 0.10; p=0.001)). We did not find evidence of an association between either lung function parameter and interval change in standardised FSIQ. Reduced FVC, but not FEV1, is independently associated with decreased cognitive ability in children. This low-magnitude association attenuates between ages 8 and 15, while no association is evident with longitudinal change in cognitive ability. Our results support a link between FVC and cognition across the life course, possibly due to shared genetic or environmental risk, rather than causation.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1093/gerona/glz057
发表时间：
2019-11-01
影响因子：
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作者：
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通讯作者：
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