Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.
Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study.
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分子亚型的代谢综合征和乳腺癌的风险：损益研究的分析。
DOI：
10.1016/j.clbc.2021.11.004
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发表时间：
2022-06
影响因子：
3.1
通讯作者：
Daramola, Adetola
中科院分区：
文献类型：
--
作者：
Akinyemiju, Tomi;Oyekunle, Taofik;Salako, Omolola;Gupta, Anjali;Alatise, Olusegun;Ogun, Gabriel;Adeniyi, Adewale;Deveaux, April;Hall, Allison;Ayandipo, Omobolaji;Olajide, Thomas;Olasehinde, Olalekan;Arowolo, Olukayode;Adisa, Adewale;Afuwape, Oludolapo;Olusanya, Aralola;Adegoke, Aderemi;Tollefsbol, Trygve O.;Arnett, Donna;Muehlbauer, Michael J.;Newgard, Christopher B.;Daramola, Adetola
代谢综合征是一组生物学异常，是心血管疾病、中风和糖尿病的已知危险因素。在一项对555名西非妇女的病例对照研究中，我们观察到代谢综合征与乳腺癌和侵袭性三阴性分子亚型密切相关，强调需要针对代谢综合征进行临床和生活方式干预，以降低这一人群的乳腺癌风险。代谢综合征（MetS）的特征是一组生物学异常。这项分析的目的是检查尼日利亚妇女中MetS与BC的关联，并首次通过分子亚型评估这种关联。MetS定义为具有以下5项中的至少3项：高血压（≥ 130/85 mm Hg）、HDL降低（< 50 mg/dL）、甘油三酯升高（> 150 mg/dL）、腰围高（≥ 80 cm）和既往诊断为糖尿病或空腹血糖水平升高（≥ 100 mg/dL）。在296例新诊断的BC病例和259例健康对照者中，采用多变量logistic回归模型估计MetS与BC总体相关性的校正比值比（aOR）和95%置信区间（95%CI）。使用多项逻辑回归模型评价每种分子亚型（管腔A、管腔B、HER 2富集和三阴性或TNBC）。调整年龄、社会人口学和生殖风险因素后，MetS与BC呈正相关（aOR：1.84，95%CI：1.07，3.16）。在分层分析中，无论BMI状态如何，MetS均与BC相关;然而，仅在正常体重女性中估计值具有显著性（aOR：3.85; 95%CI：1.25，11.90）。MetS与TNBC亚型显著相关（aOR：4.37，95%CI：1.67，11.44）;其他分子亚型的相关性无统计学显著性。MetS似乎是BC，特别是TNBC的一个强大的风险因素。公共卫生和临床干预措施可以在尼日利亚妇女中减少MetS的负担和预防BC方面提供实质性的好处。
Metabolic syndrome is a cluster of biological irregularities that is a known risk factor for cardiovascular disease, stroke, and diabetes. In a case-control study of 555 West African women, we observed that metabolic syndrome was strongly associated with breast cancer and the aggressive triple-negative molecular subtype, highlighting a need for clinical and lifestyle interventions targeting metabolic syndrome to reduce breast cancer risk in this population. Metabolic syndrome (MetS) is characterized by a cluster of biological irregularities. The purpose of this analysis was to examine the association of MetS with BC among Nigerian women, and for the first time evaluate this association by molecular subtype. MetS was defined as having at least 3 out of 5 of: high blood pressure (≥ 130/85 mm Hg), reduced HDL (< 50 mg/dL), elevated triglyceride (> 150 mg/dL), high waist circumference (≥ 80 cm), and prior diagnosis of diabetes or elevated fasting glucose level (≥ 100 mg/dL). Among 296 newly diagnosed BC cases and 259 healthy controls, multivariable logistic regression models were utilized to estimate adjusted odds ratios (aOR) and 95% confidence intervals (95% CI) for the association between MetS and BC overall. Multinomial logistic regression models were used to evaluate each molecular subtype (Luminal A, Luminal B, HER2-enriched and triple-negative or TNBC). After adjusting for age, socio-demographic and reproductive risk factors, there was a positive association between MetS and BC (aOR: 1.84, 95% CI: 1.07, 3.16). In stratified analyses, MetS was associated with BC regardless of BMI status; however, the estimate was significant only among normal weight women (aOR: 3.85; 95% CI: 1.25, 11.90). MetS was significantly associated with TNBC subtype (aOR: 4.37, 95% CI: 1.67, 11.44); associations for other molecular subtypes were not statistically significant. MetS appears to be a robust risk factor for BC, particularly for TNBC. Public health and clinical interventions can provide substantial benefits in reducing the burden of MetS and preventing BC among Nigerian women.
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代谢综合征以及种族，更年期和BMI的乳腺癌和亚型的风险。
影响因子：
5.2
作者：
Dibaba DT;Braithwaite D;Akinyemiju T
通讯作者：
Akinyemiju T
DOI：
10.1161/atvbaha.107.151092
发表时间：
2008-04-01
影响因子：
8.7
作者：
Grundy, Scott M.
通讯作者：
Grundy, Scott M.
影响因子：
3.9
作者：
Adesunkanmi, A. R. K.;Lawal, O. O.;Durosimi, M. A.
通讯作者：
Durosimi, M. A.
影响因子：
37.8
作者：
Alberti, K. G. M. M.;Eckel, Robert H.;Smith, Sidney C., Jr.
通讯作者：
Smith, Sidney C., Jr.
影响因子：
3.8
作者：
Berrino, Franco;Villarini, Anna;Pasanisi, Patrizia
通讯作者：
Pasanisi, Patrizia