[(18)F]FDG and [(18)F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus.
[(18)F]FDG and [(18)F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus.
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DOI：
10.1007/s12350-021-02781-w
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发表时间：
2022-08
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虽然[18F]-氟脱氧葡萄糖（[18F]FDG）摄取与动脉炎症有关，但[18F]-氟化钠（[18F]NaF）是动脉微钙化的标志。在一项2型糖尿病（T2DM）患者的纵向研究中，我们旨在研究两种PET标志物随时间的前瞻性相关性，以及它们是否与全身性动脉疾病的进展具有前瞻性（[18F]FDG）和回顾性（[18F]NaF）的相关性。对10例无心血管病史的早期T2DM患者（70%为男性，中位年龄63岁）的基线FDG PET/低剂量（LD） CT扫描与5年随访的NaF/LDCT扫描进行比较[18F]。通过将10条动脉的最大标准化摄取值（SUVmax）除以下腔静脉的最大标准化摄取值（SUVmax），系统活性以平均靶本比（meanantbr）表示。ct评估的宏观钙化进行视觉评分，并表示为钙化斑块（CP）评分。用颈-股脉波速度（PWV）评估动脉僵硬度。五年变化绝对用delta （Δ）表示，相对用%变化表示。基线meanTBR[18F]FDG与5年随访meanTBR[18F]NaF呈正相关（r = 0.709, P = 0.022）。meanTBR[18F]NaF与ΔCPscore、基线时CPscore、随访时均呈正相关（r = 0.845, P = 0.002; r = 0.855, P = 0.002），但与CPscore、PWV %变化无关。这项概念验证性研究表明，全身性动脉炎症是全身性动脉微钙化发展的重要致病因素。在线版本包含补充材料，可在10.1007/s12350-021-02781-w获得。
While [18F]-fluordeoxyglucose ([18F]FDG) uptake is associated with arterial inflammation, [18F]-sodium fluoride ([18F]NaF) is a marker for arterial micro-calcification. We aimed to investigate the prospective correlation between both PET markers over time and whether they are prospectively ([18F]FDG) and retrospectively ([18F]NaF) related to progression of systemic arterial disease in a longitudinal study in patients with type 2 diabetes mellitus (T2DM). Baseline [18F]FDG PET/Low Dose (LD) Computed Tomography (CT) scans of ten patients with early T2DM without cardiovascular history (70% men, median age 63 years) were compared with five-year follow-up [18F]NaF/LDCT scans. Systemic activity was expressed as mean target-to-background ratio (meanTBR) by dividing the maximal standardized uptake value (SUVmax) of ten arteries by SUVmean of the caval vein. CT-assessed macro-calcifications were scored visually and expressed as calcified plaque (CP) score. Arterial stiffness was assessed with carotid-femoral pulse wave velocity (PWV). Five-year changes were expressed absolutely with delta (Δ) and relatively with %change. Baseline meanTBR[18F]FDG was strongly correlated with five-year follow-up meanTBR[18F]NaF (r = 0.709, P = .022). meanTBR[18F]NaF correlated positively with ΔCPscore, CPscore at baseline, and follow-up (r = 0.845, P = .002 and r = 0.855, P = .002, respectively), but not with %change in CPscore and PWV. This proof-of-concept study demonstrated that systemic arterial inflammation is an important pathogenetic factor in systemic arterial micro-calcification development. The online version contains supplementary material available at 10.1007/s12350-021-02781-w.
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影响因子：
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作者：
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