Revising a Self-Regulation Phenotype for Depression Through Individual Differences in Macroscale Brain Organization.

Revising a Self-Regulation Phenotype for Depression Through Individual Differences in Macroscale Brain Organization.
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通过大尺度脑组织的个体差异修正抑郁症的自我调节表型。

DOI:
10.1177/09637214221149742
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发表时间:
2023-08
影响因子:
7.2
通讯作者:
Hariri, Ahmad R.
Hariri, Ahmad R.
中科院分区:
心理学1区
文献类型:
--
作者:
Strauman, Timothy J.;Hariri, Ahmad R.

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Self-regulation denotes the processes by which people initiate, maintain, and control their own thoughts, behaviors, or emotions to produce a desired outcome or avoid an undesired outcome. Self-regulation brings the influence of distal factors such as biology, temperament, and socialization history onto cognition, motivation, and behavior. Dysfunction in self-regulation represents a contributory causal factor for psychopathology. Accordingly, we previously proposed a risk phenotype model for depression drawing from regulatory focus theory and traditional task-based fMRI studies. In this article, we revise and expand our risk phenotype model using insights from new methodologies allowing quantification of individual differences in task-free macroscale brain organization. We offer a set of hypotheses as examples of how examination of intrinsic macroscale brain organization can extend and enrich investigations of self-regulation and depression. In doing so, we hope to promote a useful heuristic for model development and for identifying transdiagnostic risk phenotypes in psychopathology.
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